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Cutoff Value of Phase Angle by Bioelectrical Impedance Analysis at Admission as a Prognostic Factor in Patients with Acute Heart Failure
Published on: June 10, 2025
151
Association Between End-Stage Liver Disease and Incident Heart Failure in an Integrated Health System
Sarah Chuzi1, Yoshihiro Tanaka2,3, Avni Bavishi4
1Division of Cardiology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA. sarah-chuzi@northwestern.edu.
Journal of General Internal Medicine
|April 24, 2023
Summary
End-stage liver disease (ESLD) significantly increases heart failure (HF) risk by 4.67 times, independent of other conditions. The majority of these cases involve HF with preserved ejection fraction.
Area of Science:
- Cardiology
- Hepatology
- Internal Medicine
Background:
- End-stage liver disease (ESLD) and heart failure (HF) frequently coexist, contributing to substantial morbidity and mortality.
- The incidence of HF in patients with ESLD is not well-established.
Purpose of the Study:
- To investigate the association between ESLD and the development of incident HF within a real-world clinical setting.
- To quantify the risk of HF in patients with ESLD compared to those without.
Main Methods:
- Retrospective analysis of electronic health records from a large integrated health system.
- Included patients with ESLD and frequency-matched controls without ESLD.
- Incident HF was identified via ICD codes and physician review; survival analysis used Kaplan-Meier and Cox proportional hazards models, adjusting for metabolic factors.
Main Results:
- The study included 5004 patients (2502 with ESLD).
- Over a median follow-up of 2.3 years, 121 incident HF cases were recorded.
- Patients with ESLD had a significantly higher risk of incident HF (adjusted HR: 4.67; p < 0.001).
Conclusions:
- ESLD is a significant independent risk factor for developing incident HF.
- The predominant HF phenotype in ESLD patients is HF with preserved ejection fraction (HFpEF).
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