Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pulmonary Function Tests01:25

Pulmonary Function Tests

397
Pulmonary Function Tests (PFTs)
Pulmonary Function Tests are crucial diagnostic tools for assessing respiratory function, particularly in patients with chronic respiratory disorders. They comprehensively evaluate lung volumes, ventilatory function, breathing mechanics, diffusion, and gas exchange. These tests help diagnose pulmonary diseases and play a significant role in monitoring disease progression, evaluating disability, and assessing response to therapy.
PFTs involve using a spirometer, a...
397
Respiratory Volumes01:15

Respiratory Volumes

1.6K
Respiratory volumes are crucial metrics, meticulously measured to quantify the air exchanged in and out of the lungs during various phases of the breathing cycle. These precise measurements are vital for assessing lung function, diagnosing respiratory conditions, and monitoring overall respiratory health. Each parameter provides specific insights into the mechanics of breathing and the functional capacity of the lungs.
Tidal Volume (TV) Tidal volume (TV) is the air inhaled or exhaled in a...
1.6K
Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies01:27

Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies

2.5K
Assessing and diagnosing Chronic Obstructive Pulmonary Disease (COPD) involves a detailed approach that includes a comprehensive review of medical history, physical examination, and a variety of diagnostic tests. This thorough evaluation is essential to ensure an accurate diagnosis and guide effective management strategies.
Medical History
2.5K
Lung Capacity01:47

Lung Capacity

51.0K
The air in the lungs is measured in volumes and capacities. Lung volume measures reflect the amount of air taken in, released, or left over after a lung function, like a single inhalation. Lung capacity measures are sums of two or more lung volume measures.
51.0K
Respiratory Capacities01:24

Respiratory Capacities

861
Respiratory capacities are crucial indicators of lung function, representing the maximum amount of air an individual's respiratory system can handle during various breathing phases.
One key metric is the Inspiratory Capacity (IC), which represents the maximum amount of air that can be inhaled with full effort. IC is calculated by summing the tidal volume and inspiratory reserve volume, typically ranging from 2.4 to 3.6 liters.
The Functional Residual Capacity (FRC) represents the air in the...
861
Factors Affecting Pulmonary Ventilation01:19

Factors Affecting Pulmonary Ventilation

1.5K
Besides the pressure difference between the external environment and the lungs, the airflow rate and ease of pulmonary ventilation are also influenced by three other factors: surface tension of the fluid in the alveoli, compliance of the lungs, and airway resistance.
Alveolar Surface Tension
The alveolar fluid lines the luminal surface of the alveoli and exerts a force called surface tension. This force is caused by the polar water molecules in the liquid being more strongly attracted to each...
1.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Exposure to Polycyclic Aromatic Hydrocarbons, but Not to Dust or Fluorides, in the Norwegian Aluminum Industry Is Associated With Accelerated Annual Decline in Lung Function.

American journal of industrial medicine·2026
Same author

Occupational risk factors for asthma exacerbation in adults: a five-year follow-up of the Norwegian Telemark study cohort.

The Journal of asthma : official journal of the Association for the Care of Asthma·2025
Same author

Occupational exposure and chronic bronchitis in a sample of the general population in Telemark, Norway: a two-phased cross-sectional study.

Occupational and environmental medicine·2025
Same author

Validation of a semi-quantitative method to assess interstitial lung disease severity and progression in systemic sclerosis by standard and low-dose HRCT scans.

RMD open·2025
Same author

Occupational Exposure to Inhalable Agents Is Associated With Reduced Work Ability: A Prospective Cohort Study in Norway.

Journal of occupational and environmental medicine·2024
Same author

Occupational exposure and new-onset asthma in the population-based Telemark study: a 5-year follow-up.

BMJ open·2024

Related Experiment Video

Updated: Aug 1, 2025

Author Spotlight: Integrating Alveolar-Capillary Reserve Measurements in Exercise Adaptation and Therapeutic Strategies
08:44

Author Spotlight: Integrating Alveolar-Capillary Reserve Measurements in Exercise Adaptation and Therapeutic Strategies

Published on: February 2, 2024

772

Comparison of different reference values for lung function: implications of inconsistent use among centers.

Henrik Mangseth1, Liv Ingunn Bjoner Sikkeland2,3, Michael Thomas Durheim2,3

  • 1Department of Respiratory Medicine, Oslo University Hospital, Sognsvannsveien, Rikshospitalet, Oslo, 20,0372, Norway. hemang@ous-hf.no.

BMC Pulmonary Medicine
|April 24, 2023
PubMed
Summary

Changing pulmonary function test (PFT) reference values from ECSC to GLI impacts diagnostic criteria, especially for females. Consistent nationwide implementation of Global Lung Function Initiative (GLI) values is crucial for equitable patient care.

Keywords:
Clinical aspectsInterpretationLung function testsReference values

More Related Videos

Employing the Forced Oscillation Technique for the Assessment of Respiratory Mechanics in Adults
06:11

Employing the Forced Oscillation Technique for the Assessment of Respiratory Mechanics in Adults

Published on: February 9, 2022

5.6K
Combining Volumetric Capnography And Barometric Plethysmography To Measure The Lung Structure-function Relationship
08:25

Combining Volumetric Capnography And Barometric Plethysmography To Measure The Lung Structure-function Relationship

Published on: January 8, 2019

9.4K

Related Experiment Videos

Last Updated: Aug 1, 2025

Author Spotlight: Integrating Alveolar-Capillary Reserve Measurements in Exercise Adaptation and Therapeutic Strategies
08:44

Author Spotlight: Integrating Alveolar-Capillary Reserve Measurements in Exercise Adaptation and Therapeutic Strategies

Published on: February 2, 2024

772
Employing the Forced Oscillation Technique for the Assessment of Respiratory Mechanics in Adults
06:11

Employing the Forced Oscillation Technique for the Assessment of Respiratory Mechanics in Adults

Published on: February 9, 2022

5.6K
Combining Volumetric Capnography And Barometric Plethysmography To Measure The Lung Structure-function Relationship
08:25

Combining Volumetric Capnography And Barometric Plethysmography To Measure The Lung Structure-function Relationship

Published on: January 8, 2019

9.4K

Area of Science:

  • Pulmonary Medicine
  • Clinical Diagnostics
  • Respiratory Physiology

Background:

  • Pulmonary function tests (PFTs) require established reference values for accurate interpretation.
  • Norway currently uses European Coal and Steel Community (ECSC) values, despite recommendations for the newer Global Lung Function Initiative (GLI) standards.
  • This study investigates the clinical impact of transitioning from ECSC to GLI reference values.

Purpose of the Study:

  • To compare the effects of using ECSC versus GLI reference values for spirometry, DLCO, and lung volumes.
  • To assess the differences in percent predicted values and lower limits of normal (LLN) between the two reference sets.
  • To evaluate the clinical implications of this change in a cohort of adult patients.

Main Methods:

  • Utilized PFT data from 577 adults (aged 18-85, 45% female).
  • Compared ECSC and GLI reference values for FVC, FEV1, DLCO, TLC, and RV.
  • Calculated percent predicted values and LLN, employing Bland-Altman plots to assess agreement.

Main Results:

  • GLI values showed lower FVC/FEV1 and higher DLCO/RV predictions compared to ECSC in both sexes.
  • Differences were most pronounced in females: mean difference of 15 pp for DLCO and 17 pp for RV.
  • GLI identified 23% of females with DLCO below LLN, versus 49% with ECSC.

Conclusions:

  • The shift from ECSC to GLI reference values has significant implications for diagnosing and treating respiratory conditions.
  • Discrepancies affect healthcare benefits, clinical trial eligibility, and diagnostic criteria.
  • Nationwide, consistent implementation of GLI reference values is essential for equitable patient care.