Related Experiment Video
Updated: Aug 1, 2025
07:20
Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents
Published on: May 28, 2014
14.0K
Recent Advances of Platinum-Based Anticancer Complexes in Combinational Multimodal Therapy
Tianyuan Zhong1,2, Jie Yu1,2, Yong Pan1,2
1Faculty of Chemistry, Northeast Normal University, Changchun, 130024, China.
Advanced Healthcare Materials
|April 25, 2023
Summary
Combination therapy using platinum drugs offers a promising strategy to enhance anti-cancer efficacy and overcome drug resistance. This approach combines platinum drugs with novel modalities to improve treatment outcomes and reduce toxicity.
Area of Science:
- Oncology
- Materials Science
- Nanotechnology
Background:
- Platinum-based chemotherapy is a cornerstone in cancer treatment but faces limitations due to systemic toxicity and acquired drug resistance.
- Developing novel strategies to enhance the therapeutic index of platinum drugs is critical for improving patient outcomes.
Purpose of the Study:
- To review current advancements in platinum-based combination therapies for cancer treatment.
- To explore innovative combinations of platinum drugs with emerging therapeutic modalities.
Main Methods:
- Literature review of platinum-based combination strategies.
- Summary of platinum complexes combined with gene editing, ROS-based therapy, thermal therapy, immunotherapy, photoactivation, supramolecular self-assembly, and imaging.
Main Results:
- Combination therapies demonstrate potential for additive or synergistic tumor growth inhibition and metastasis reduction.
- These combinations may mitigate systemic toxicity and overcome platinum resistance.
- Various platinum-based complexes are being developed for synergistic effects with other treatments.
Conclusions:
- Platinum-based combination therapy represents a promising avenue for overcoming limitations of traditional platinum drugs.
- Further research into novel synthetic strategies and therapeutic combinations is essential for developing more effective platinum-based anti-cancer agents.
More Related Videos
Related Concept Videos
02:50Combination Therapies and Personalized Medicine
5.0K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
5.0K
02:49Cancer Therapies
7.8K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
7.8K
02:57Targeted Cancer Therapies
7.7K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.7K
02:56Treatment Resistant Cancers
3.4K
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.4K
01:27Tumor Immunotherapy
593
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
593
01:27Combined Effects of Drugs: Synergism
4.2K
Synergism is a useful mechanism where combining two or more drugs is more effective than each constituent used alone. Such combinations are also called supra-additive interactions. The drugs collectively enhance the final therapeutic effect by acting on different targets. Another advantage is that the low dose of each constituent drug is sufficient to achieve the desired effect. This helps reduce the duration of therapy and lower the adverse effects of these drugs.
Such synergistic combinations...
Such synergistic combinations...
4.2K