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Murine model for chronic rhinosinusitis: an interventional study.

Amr F Hamour1, John Jw Lee2, Ewa Wasilewski3

  • 1Department of Otolaryngology - Head and Neck Surgery, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada.

Journal of Otolaryngology - Head & Neck Surgery = Le Journal D'Oto-Rhino-Laryngologie Et De Chirurgie Cervico-Faciale
|April 25, 2023
PubMed
Summary
This summary is machine-generated.

A new mouse model effectively mimics chronic rhinosinusitis (CRS) inflammation. This model shows promise for testing new treatments for eosinophilic CRS.

Keywords:
Animal modelChronic rhinosinusitisEosinophilic chronic rhinosinusitisHistological markersInflammation

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Area of Science:

  • Immunology
  • Otorhinolaryngology
  • Pharmacology

Background:

  • Chronic rhinosinusitis (CRS) is a complex sinonasal inflammatory disease.
  • Developing targeted treatments requires a reproducible animal model.
  • This study optimizes a murine model for eosinophilic CRS.

Purpose of the Study:

  • Establish benchmark histological markers for a murine eosinophilic CRS model.
  • Validate the model's fidelity in evaluating intranasal treatments.
  • Assess the efficacy of mometasone in reversing CRS-induced histopathological changes.

Main Methods:

  • Forty-five Balb/c mice underwent a 7-week protocol.
  • CRS was induced via ovalbumin (OVA) sensitization and intranasal OVA with Aspergillus oryzae protease.
  • Histological analysis and blood counts were performed; CRS mice received saline or mometasone treatment.

Main Results:

  • CRS model mice exhibited increased eosinophilic infiltration, hyaline droplets, Charcot-Leyden crystals, and epithelial thickness.
  • Mometasone treatment significantly reversed these observed histopathological changes.
  • The model successfully replicated key features of eosinophilic CRS.

Conclusions:

  • The developed murine model induces significant eosinophilic inflammation in sinonasal mucosa.
  • This inflammation is reversible with mometasone treatment.
  • The model is suitable for evaluating the efficacy of therapeutics targeting CRS.