Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Aug 1, 2025

Surface Engineering of Pancreatic Islets with a Heparinized StarPEG Nanocoating
05:35

Surface Engineering of Pancreatic Islets with a Heparinized StarPEG Nanocoating

Published on: June 23, 2018

7.4K

Heparin Prowess: Favorable Vascular-Immune Reprogramming in Pancreatic Cancer.

Murray Korc1

  • 1Department of Developmental and Cell Biology, Chao Family Comprehensive Cancer Center, University of California Irvine, Irvine, California.

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
|April 26, 2023
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

Anticoagulant Drugs: Low-Molecular-Weight Heparins01:30

Anticoagulant Drugs: Low-Molecular-Weight Heparins

782
Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
782
Psychoneuroimmunology: Diabetes and Cancer01:19

Psychoneuroimmunology: Diabetes and Cancer

51
Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
51

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

MicroRNA Expression in a Readily Accessible Common Hepatic Artery Lymph Node Predicts Time to Pancreatic Cancer Recurrence Postresection.

Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract·2016
Same journal

Clinical Validation of a Multiplex Urine Biomarker Assay for Surveillance of Recurrent Bladder Cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research·2026
Same journal

Epigenetic Liquid Biopsy Enables Universal Mutation-Agnostic Molecular Surveillance for High-Risk Neuroblastoma.

Clinical cancer research : an official journal of the American Association for Cancer Research·2026
Same journal

Claudin 18.2 Targeting: A Pan-Cancer Perspective.

Clinical cancer research : an official journal of the American Association for Cancer Research·2026
Same journal

High-Sensitivity ctDNA Analysis Uncovers Relevant Signals Missed by NGS in Pancreatic Cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research·2026
Same journal

Pediatric Brain Tumor Consortium phase 1 study of CD40 agonist sotigalimab in pediatric and young adult patients with recurrent CNS tumors and newly-diagnosed DIPG.

Clinical cancer research : an official journal of the American Association for Cancer Research·2026
Same journal

A randomized phase 2 study of combination atezolizumab and varlilumab (CDX-1127) with or without cobimetinib in previously-treated unresectable biliary tract cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research·2026
See all related articles

Heparin enhances immunotherapy by normalizing blood vessels and increasing immune cell infiltration in pancreatic and colorectal cancer models. This suggests heparin-based therapies may be effective against immunotherapy-resistant "cold" tumors.

Area of Science:

  • Oncology
  • Immunology
  • Vascular Biology

Background:

  • Pancreatic and colorectal cancers often exhibit resistance to immunotherapy.
  • Developing strategies to overcome this resistance is crucial for improving patient outcomes.

Discussion:

  • Heparin demonstrated efficacy in overcoming immunotherapy resistance in preclinical cancer models.
  • The mechanism involves heparin-induced vascular normalization, promoting CD8+ T-cell infiltration and M1 macrophage polarization.
  • These effects are particularly relevant for "cold" tumors, which are typically less responsive to immunotherapy.

Key Insights:

  • Heparin acts as a vascular-normalizing agent, enhancing the tumor microenvironment for immune attack.
  • Successful immune cell infiltration (CD8+ T-cells) and M1 macrophage polarization are key mediators of heparin's beneficial effects.

More Related Videos

Ultrasound-Guided Orthotopic Implantation of Murine Pancreatic Ductal Adenocarcinoma
06:21

Ultrasound-Guided Orthotopic Implantation of Murine Pancreatic Ductal Adenocarcinoma

Published on: November 19, 2019

11.3K
Author Spotlight: Validating Cancer Therapy Responses with Desmoplastic Spheroid Models
03:42

Author Spotlight: Validating Cancer Therapy Responses with Desmoplastic Spheroid Models

Published on: September 27, 2024

1.5K

Related Experiment Videos

Last Updated: Aug 1, 2025

Surface Engineering of Pancreatic Islets with a Heparinized StarPEG Nanocoating
05:35

Surface Engineering of Pancreatic Islets with a Heparinized StarPEG Nanocoating

Published on: June 23, 2018

7.4K
Ultrasound-Guided Orthotopic Implantation of Murine Pancreatic Ductal Adenocarcinoma
06:21

Ultrasound-Guided Orthotopic Implantation of Murine Pancreatic Ductal Adenocarcinoma

Published on: November 19, 2019

11.3K
Author Spotlight: Validating Cancer Therapy Responses with Desmoplastic Spheroid Models
03:42

Author Spotlight: Validating Cancer Therapy Responses with Desmoplastic Spheroid Models

Published on: September 27, 2024

1.5K
  • The study highlights heparin's potential as an adjuvant therapy in combination with immunotherapy.

    • Outlook:

    • Further investigation into heparin-anchored therapies for pancreatic cancer and other "cold" tumors is warranted.
    • Clinical translation of these findings could offer new treatment avenues for immunotherapy-resistant cancers.
    • Optimizing heparin's delivery and combination strategies will be essential for future therapeutic development.