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Post-Myocardial Infarction Heart Failure in Closed-chest Coronary Occlusion/Reperfusion Model in Göttingen Minipigs and Landrace Pigs
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Long-term prognostic impact of subclinical myocardial dysfunction in patients recovered from COVID-19

Francesco Cannata1,2, Giuseppe Pinto1, Mauro Chiarito1,2

  • 1IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy.

Echocardiography (Mount Kisco, N.Y.)
|April 26, 2023
PubMed

Insights

Subclinical myocardial dysfunction, identified by echocardiography in recovered COVID-19 patients, predicts major adverse cardiovascular events. Long-COVID symptoms did not show prognostic relevance for long-term cardiovascular outcomes.

Area of Science:

  • Cardiology
  • Infectious Diseases
  • Pulmonology

Background:

  • Cardiovascular sequelae are a concern for patients recovering from coronavirus disease 2019 (COVID-19).
  • Subclinical myocardial dysfunction and long-COVID symptoms are frequently observed post-COVID-19 recovery.
  • The long-term prognostic significance of these conditions requires further investigation.

Purpose of the Study:

  • To determine the long-term prognostic role of subclinical myocardial dysfunction in COVID-19 survivors.
  • To assess the prognostic value of long-COVID condition in patients after COVID-19 pneumonia.
  • To identify predictors of major adverse cardiovascular events (MACE) in this population.

Main Methods:

  • Prospective follow-up of 110 patients hospitalized with COVID-19 pneumonia.
  • Clinical and echocardiographic evaluation at 7 months, followed by 21 months of clinical follow-up.
  • Primary outcome defined as MACE (myocardial infarction, stroke, heart failure hospitalization, all-cause mortality).

Main Results:

  • Subclinical myocardial dysfunction (left ventricular global longitudinal strain ≥-18%) was detected in 34% of patients at 7 months.
  • This dysfunction was associated with an increased risk of long-term MACE (AUC: .73) and was an independent predictor.
  • Long-COVID condition did not correlate with a worse long-term prognosis.

Conclusions:

  • Subclinical myocardial dysfunction affects one-third of COVID-19 pneumonia survivors and predicts MACE.
  • Speckle-tracking echocardiography aids in risk-stratifying post-COVID-19 patients.
  • Long-COVID condition lacks prognostic relevance for long-term cardiovascular outcomes.
Abstract

Keywords:
COVID-19advanced echocardiographyglobal longitudinal strainlong-COVIDsubclinical myocardial dysfunction

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