Related Experiment Video

Updated: Jul 15, 2026

A Mouse Model of Intestinal Partial Obstruction
07:33

A Mouse Model of Intestinal Partial Obstruction

Published on: March 5, 2018

Chronic intestinal pseudoobstruction in young children

S Anuras, F A Mitros, R T Soper

    Gastroenterology
    |July 1, 1986
    PubMed

    Insights

    This study investigated chronic intestinal pseudoobstruction in young children, finding severe gastrointestinal and urinary tract dysfunction despite mostly normal histology. Early-onset symptoms like infections and bladder issues are key indicators.

    Area of Science:

    • Pediatric Gastroenterology
    • Urology
    • Gastrointestinal Motility Disorders

    Background:

    • Chronic intestinal pseudoobstruction (CIPO) is a rare, severe motility disorder.
    • Early-onset CIPO in children presents diagnostic challenges.
    • Associated urinary tract dysfunction is frequently observed.

    Observation:

    • Eight young children (4 boys, 4 girls) with CIPO were studied.
    • Symptoms including recurrent urinary tract infections and dysuria appeared between a few weeks and 5 years of age.
    • All patients exhibited marked gastrointestinal tract dilatation and megacystis.

    Findings:

    • Conventional pathology of gastrointestinal specimens was normal in 5/8 patients; abnormalities included fibrosis and lipofuscin pigment in smooth muscle in 2/8.
    • Myenteric plexus examination was normal in the 2 patients tested.
    • Urinary bladder biopsies showed collagen separation of smooth muscle cells in 3 patients.
    • Intestinal manometry revealed weak, infrequent contractions in 3 patients.

    Implications:

    • Severe gastrointestinal and urinary tract dysfunction can occur in children with CIPO and relatively normal histologic findings.
    • This suggests non-histologic factors or subtle abnormalities may underlie the severe functional deficits.
    • Further research into the pathophysiology of pediatric CIPO is warranted to improve diagnosis and management.

    More Related Videos

    An Immature Murine Model of Reversible Unilateral Ureteral Obstruction06:37

    An Immature Murine Model of Reversible Unilateral Ureteral Obstruction

    Published on: April 4, 2025

    Laparoscopic Choledochal Cyst Excision and Roux-en-Y Choledochojejunostomy in Adults04:14

    Laparoscopic Choledochal Cyst Excision and Roux-en-Y Choledochojejunostomy in Adults

    Published on: February 28, 2025

    Related Concept Videos

    Esophageal Strictures-I: Introduction01:30

    Esophageal Strictures-I: Introduction

    Esophageal strictures involve abnormal narrowing or tightening of the esophagus. They vary in length and severity, ranging from mild constriction to complete obstruction, and are classified as benign (noncancerous) or malignant (cancerous).
    Etiology
    The primary cause of esophageal strictures is long-standing gastroesophageal reflux disease (GERD), accounting for about 70 to 80% of adult cases. Chronic acid reflux can lead to injury and scarring of the esophageal lining, culminating in...
    Esophageal Strictures-II: Clinical Features and Management01:26

    Esophageal Strictures-II: Clinical Features and Management

    Patients with esophageal strictures often experience a range of symptoms. Initially, they may have difficulty swallowing solid foods, which can progress to include liquids. Additional symptoms may involve chest pain or discomfort, regurgitating food and fluids, heartburn, unintentional weight loss, coughing or choking during meals, and hoarseness.
    Healthcare providers should gather a comprehensive medical history and conduct a physical examination for diagnosis. If esophageal stricture is...
    Inflammatory Bowel Disease V: Surgical Management01:21

    Inflammatory Bowel Disease V: Surgical Management

    Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
    Here are some common surgical interventions for IBD:
    Pyloric Obstruction01:11

    Pyloric Obstruction

    Pyloric obstruction, also referred to as gastric outlet obstruction, is a condition characterized by narrowing or blockage at the pylorus—the muscular valve regulating the flow of stomach contents into the duodenum. When this passage becomes impaired, the stomach cannot effectively empty its contents into the small intestine. This disruption leads to a range of gastrointestinal symptoms, including early satiety, bloating, epigastric pain, postprandial nausea, persistent vomiting, and...
    Intestinal Obstruction I: Introduction01:29

    Intestinal Obstruction I: Introduction

    Intestinal obstruction is a partial or complete blockage of the small or large intestine that disrupts the normal flow of intestinal contents through the lumen. This interruption impairs digestion, absorption, and fluid balance, and may lead to serious complications if not treated promptly.Mechanical ObstructionMechanical obstruction occurs when a physical blockage prevents intestinal contents from passing, arising from within the lumen or the bowel wall, or from external compression.Adhesions,...
    Intestinal Obstruction II: Pathophysiology01:07

    Intestinal Obstruction II: Pathophysiology

    Intestinal obstruction triggers a series of physiological responses, starting with gas and fluid accumulation in the bowel segment proximal to the obstruction, leading to distension. This distended intestine compresses the diaphragm, hindering lung expansion and potentially leading to reduced respiratory effort, atelectasis, and pneumonia.To overcome the blockage, the gut intensifies contractions, causing colicky abdominal pain, nausea, and vomiting, which reduces fluid and food intake and...