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Yeast As a Chassis for Developing Functional Assays to Study Human P53
Published on: August 4, 2019
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TP53 somatic mutations in Asian breast cancer are associated with subtype-specific effects
Mohana Eswari Ragu1, Joanna Mei Ch'wan Lim2, Pei-Sze Ng2
1Cancer Research Malaysia, No. 1, Jalan SS12/1A, 47500, Subang Jaya, Malaysia. mohana.eswari@cancerresearch.my.
Breast Cancer Research : BCR
|April 26, 2023
Summary
TP53 mutations impact Asian breast tumors differently across subtypes. Luminal A and B tumors show greater TP53 mutation effects, suggesting targeted therapies may be more effective for these subtypes in Asian populations.
Area of Science:
- Genomic analysis of cancer
- Molecular oncology
- Breast cancer research
Background:
- Genomic studies reveal higher TP53 mutation prevalence in Asian breast cancer patients compared to Caucasians.
- The specific impact of TP53 mutations on Asian breast tumors remains under-investigated.
Purpose of the Study:
- To analyze the impact of TP53 somatic mutations on breast tumors within the Malaysian Breast Cancer cohort.
- To investigate the relationship between TP53 mutations and PAM50 subtypes using genomic and transcriptomic data.
Main Methods:
- Analysis of 492 breast cancer samples from the Malaysian Breast Cancer cohort.
- Comparison of whole exome and transcriptome data from tumors with mutant versus wild-type TP53.
- Assessment of TP53 mutation impact across different PAM50 subtypes.
Main Results:
- The effect of TP53 somatic mutations varies significantly across breast cancer subtypes.
- TP53 mutations correlate with higher HR deficiency scores and increased gene expression in luminal A and B tumors.
- mTORC1 signaling and glycolysis pathways are consistently dysregulated in tumors with TP53 mutations across subtypes.
Conclusions:
- TP53 mutation impact differs between breast cancer subtypes in Asian populations.
- Targeted therapies focusing on TP53 or downstream pathways like mTORC1 signaling and glycolysis may offer greater efficacy for luminal A and B tumors in Asian patients.
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