Disulfidptosis: a new target for metabolic cancer therapy

Area of Science:

• Oncology
• Metabolic pathways
• Cell death mechanisms

Background:

• Altered cellular metabolism is a key characteristic of cancer, presenting a therapeutic vulnerability.
• Regulated cell death (RCD) is critical in cancer metabolic therapy.
• Disulfidptosis is a newly identified metabolic-related RCD pathway.

Approach:

• This review summarizes the underlying mechanisms of disulfidptosis.
• It outlines potential future research directions for disulfidptosis.
• The review discusses challenges in the clinical translation of disulfidptosis.

Key Points:

• Disulfidptosis is a novel form of regulated cell death linked to metabolic dysregulation in cancer.
• Inhibiting glucose transporters (GLUTs) can induce disulfidptosis, leading to cancer cell death.
• Preclinical studies demonstrate the potential of GLUT inhibitors in triggering disulfidptosis for cancer treatment.

Conclusions:

• Disulfidptosis represents a new therapeutic target in oncology.
• Targeting metabolic pathways through GLUT inhibitors offers a promising approach for cancer treatment.
• Further research is needed to overcome challenges in the clinical application of disulfidptosis-based therapies.