Related Experiment Video
Updated: Aug 1, 2025
07:25
A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
Published on: March 6, 2018
13.2K
Emerging treatment options for prostate cancer.
Mohammad Atiq1, Elias Chandran1, Fatima Karzai1
1Genitourinary Malignancy Branch, National Cancer Institute, Bethesda, MD, USA.
Expert Review of Anticancer Therapy
|April 27, 2023
Summary
Prostate cancer treatment advances include androgen-receptor pathway inhibitors and docetaxel chemotherapy. Novel agents like lutetium radioligand therapy improve survival, but new treatments are needed post-progression.
Area of Science:
- Oncology
- Medical Science
Background:
- Androgen deprivation therapy (ADT) is a cornerstone for advanced prostate cancer.
- Androgen-receptor pathway inhibitors (ARPI) and docetaxel chemotherapy offer survival benefits.
- Disease progression is inevitable, necessitating novel therapeutic strategies.
Approach:
- This review examines pivotal trials for U.S. FDA-approved metastatic prostate cancer agents.
- It explores novel therapies including PSMA-targeting agents, radioligands, and cell-based therapies.
- The review also covers chimeric antigen receptor T-cell, BiTE, and antibody drug conjugates.
Key Points:
- The metastatic castrate-resistant prostate cancer (mCRPC) treatment landscape has expanded.
- New options include sipuleucel-T, radium, cabazitaxel, PARP inhibitors, and lutetium.
- Sequencing of these therapies is crucial for optimal patient outcomes.
Conclusions:
- While current treatments show incremental benefits, novel therapies are essential.
- Lutetium radioligand therapy has demonstrated survival improvements.
- Further research is critical for agents effective after lutetium progression.
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