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Aggregation-Induced Emission Luminogens for Cell Death Research.

Yunfei Zuo1, Hanchen Shen1, Feiyi Sun1

  • 1Department of Chemistry, Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction, and Guangdong-Hong Kong-Macau Joint Laboratory of Optoelectronic and Magnetic Functional Materials, Division of Life Science, and State Key Laboratory of Molecular Neuroscience, The Hong Kong University of Science & Technology, Clear Water Bay, Kowloon, Hong Kong 999077, P.R. China.

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Aggregation-induced emission luminogens (AIEgens) offer promising theranostic potential for monitoring and controlling cell death. This review explores AIE materials

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Area of Science:

  • Biomedical Engineering
  • Materials Science
  • Cell Biology

Background:

  • Cell death is intricately linked to numerous diseases, making its monitoring and control a key therapeutic strategy.
  • Aggregation-induced emission luminogens (AIEgens) possess unique optical properties in aggregate states, making them suitable for theranostic applications.
  • The use of AIE materials in studying cell death mechanisms is an emerging field with significant clinical promise.

Purpose of the Study:

  • To review the current research landscape and understanding of AIE materials in various cell death pathways.
  • To highlight the potential of AIE materials as theranostic agents for cell death-related diseases.
  • To provide new insights and encourage further research contributions in this rapidly advancing field.

Main Methods:

  • Comprehensive literature review of AIE materials applied to cell death research.
  • Analysis of AIEgens' properties and their utility in monitoring diverse cell death subroutines.
  • Discussion of the clinical potential and future directions for AIE-based theranostics.

Main Results:

  • AIE materials demonstrate significant potential for visualizing and intervening in various cell death processes.
  • The review covers AIE applications in apoptosis, necrosis, immunogenic cell death, pyroptosis, autophagy, lysosome-dependent cell death, and ferroptosis.
  • AIEgens offer advantages in sensitivity and specificity for theranostic development compared to traditional agents.

Conclusions:

  • AIE materials represent a powerful tool for advancing cell death research and developing novel theranostic strategies.
  • Further exploration of AIE applications can lead to improved diagnostics and treatments for diseases associated with aberrant cell death.
  • This review aims to stimulate further innovation and collaboration within the AIE and cell death research communities.