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Updated: Jun 11, 2026

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A Multifunctional Near-Infrared Platinum(II) Agent for High-Performance Chemo-Photothermal Therapy.

Yingying Chen1, Sheng-Yi Yang1, Xinwen Ou1

  • 1Department of Chemistry, the Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction, Department of Chemical and Biological Engineering, State Key Laboratory of Nervous System Disorders, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong SAR 999077, China.

Journal of the American Chemical Society
|June 9, 2026
PubMed
Summary
This summary is machine-generated.

This study introduces BSeTPE-Pt-ac, a novel platinum complex for advanced cancer therapy. It combines near-infrared emission, aggregation-induced emission, and photothermal effects for tumor imaging and synergistic chemo-photothermal therapy (chemo-PTT).

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Area of Science:

  • Medicinal Chemistry
  • Materials Science
  • Oncology

Background:

  • Conventional platinum-based chemotherapy has limited efficacy due to lack of diagnostic guidance.
  • Multifunctional theranostic platinum complexes offer a promising avenue for improved cancer treatment.
  • Developing agents with integrated diagnostic and therapeutic capabilities is crucial.

Purpose of the Study:

  • To design and synthesize a multifunctional platinum(II) complex (BSeTPE-Pt-ac) with near-infrared (NIR) emission, aggregation-induced emission (AIE), and photothermal effects.
  • To achieve tumor-specific imaging and synergistic chemo-photothermal therapy (chemo-PTT).
  • To identify and target key genes involved in thermal resistance for enhanced therapeutic outcomes.

Main Methods:

  • Synthesis of a bidentate platinum(II) complex (BSeTPE-Pt-ac) incorporating benzoselenadiazole and tetraphenylethylene units.
  • Characterization of photophysical properties including NIR emission, AIE, and photothermal effects.
  • Bioinformatics analysis to identify B-cell lymphoma 2 (BCL2) as a key antiapoptotic target.
  • Co-delivery of BCL2 antisense oligonucleotide and BSeTPE-Pt-ac using tumor-targeting polymers for synergistic gene regulation and therapy.

Main Results:

  • BSeTPE-Pt-ac exhibits NIR emission, AIE, and photothermal properties, enabling tumor-specific imaging.
  • Bioinformatics identified BCL2 as a critical target for overcoming thermal resistance.
  • Co-delivery strategy effectively silenced BCL2 expression, enhancing chemo-PTT efficacy.
  • The multifunctional agent demonstrated synergistic gene regulation and maximized therapeutic outcomes.

Conclusions:

  • BSeTPE-Pt-ac represents a rationally designed multifunctional platinum(II) agent integrating diagnostic and therapeutic functionalities.
  • The study highlights the potential of combining gene regulation with chemo-photothermal therapy for improved cancer treatment.
  • This work provides valuable insights for developing advanced theranostic agents for cancer therapy.