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Synthesis of a Thiol Building Block for the Crystallization of a Semiconducting Gyroidal Metal-sulfur Framework
Published on: April 9, 2018
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Silver-based coordination polymers assembled by dithioether ligands: potential antibacterial materials despite
Quentin Gaudillat1, Anna Krupp2, Thibaut Zwingelstein3
1Institut UTINAM, UMR CNRS 6213, Université de Franche-Comté, 16 route de Gray, 25030 Besançon Cedex, France. lydie.viau@univ-fcomte.fr.
Dalton Transactions (Cambridge, England : 2003)
|April 27, 2023
Summary
New 2D silver coordination polymers show antibacterial effects against Gram-negative and Gram-positive bacteria. Their stable structure ensures a sustained release of silver ions for antimicrobial applications.
Area of Science:
- Materials Science
- Nanotechnology
- Chemistry
Background:
- Antimicrobial resistance is a growing global health concern.
- Silver ions (Ag+) are known for their broad-spectrum antimicrobial properties.
- Developing stable and effective silver-based antimicrobial agents is crucial.
Purpose of the Study:
- To synthesize and characterize novel 2D silver-based coordination polymers.
- To investigate the antibacterial activity of these novel materials against Gram-negative and Gram-positive bacteria.
- To assess the stability and silver ion release profile of the synthesized coordination polymers.
Main Methods:
- Self-assembly of silver ions with acetylenic dithioether ligands.
- Characterization of the 2D coordination polymer structures.
- In vitro antibacterial assays against representative bacterial strains.
- Analysis of silver ion (Ag+) release kinetics.
Main Results:
- Successful synthesis of stable 2D silver-based coordination polymers.
- Demonstrated significant antibacterial activity against both Gram-negative and Gram-positive bacteria.
- Confirmed sustained release of silver ions (Ag+) from the polymer matrix.
- The materials exhibited good structural stability in aqueous media.
Conclusions:
- The novel 2D silver coordination polymers represent a promising new class of antimicrobial agents.
- Their efficacy is attributed to the controlled release of silver ions (Ag+).
- These materials offer potential for developing advanced antibacterial therapies and materials.
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