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Cercosporin-Photocatalyzed [4+1]- and [4+2]-Annulations of Azoalkenes Under Mild Conditions
Published on: July 17, 2020
Reshaping the Diversity of Oxidized Polyquinane Sesquiterpenoids by Cytochrome P450s
Li Rao1, Guan-Yin Yuan1, Xing-Yue Chen1
1College of Pharmaceutical Sciences, Southwest University, Chongqing 400715, P. R. China.
Abstract:
Polyquinane sesquiterpenoids (PQSTs) are complex compounds with two or three fused cabocyclopentane ring systems, and the biocatalysts for direct C-H bond oxidation on these scaffolds have rarely been discovered. In this study, we discovered two versatile fungal CYP450s capable of performing diverse oxidations on seven PQST scaffolds, resulting in the generation of 20 unique products. Our findings significantly expand the diversity of oxidized PQST scaffolds and provide important biocatalysts for the selective oxidation of inert carbons of terpenoids in future research.
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