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Author Spotlight: Effect of Left Atrial Ligation on Avian Embryonic Hearts and HLHS Implications
Published on: June 16, 2023
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What Is the Hypoplastic Left Heart Syndrome?
Robert H Anderson1, Adrian Crucean2, Diane E Spicer3
1Biosciences Division, Newcastle University, Newcastle upon Tyne NE1 7RU, UK.
Journal of Cardiovascular Development and Disease
|April 27, 2023
Summary
The definition of hypoplastic left heart syndrome (HLHS) is debated. This review argues that an intact ventricular septum is crucial for defining HLHS, impacting its genetic background and fetal development.
Area of Science:
- Pediatric Cardiology
- Developmental Biology
- Medical History
Background:
- The definition of hypoplastic left heart syndrome (HLHS) lacks consensus.
- Historical accounts of HLHS have varied in their inclusion criteria, particularly regarding ventricular septal defects.
Purpose of the Study:
- To review evidence supporting the inclusion of an intact ventricular septum in the definition of HLHS.
- To explore the implications of ventricular septal integrity on understanding HLHS etiology.
Main Methods:
- Literature review of historical and contemporary definitions of HLHS.
- Analysis of the impact of ventricular septal integrity on fetal cardiac development and disease classification.
Main Results:
- Historical definitions of HLHS by Lev, Noonan, and Nadas are examined.
- The integrity of the ventricular septum influences the interpretation of HLHS as an acquired fetal condition.
Conclusions:
- An intact ventricular septum should be a key criterion in the definition of hypoplastic left heart syndrome.
- Recognizing this criterion aids in understanding the genetic basis and developmental origins of HLHS.
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