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Related Concept Videos

Heart Valves01:16

Heart Valves

5.2K
The human heart is a complex organ with an intricate system of valves that regulate blood flow. There are two main types of valves: atrioventricular (AV) valves and semilunar valves.
The AV valves prevent the backflow of blood from the ventricles to the atria during ventricular contraction. These valves function with the assistance of the chordae tendineae and papillary muscles. When the ventricles are relaxed, the chordae tendineae are slack, allowing blood to flow from the atria into the...
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Mitral Valve Prolapse I: Introduction01:27

Mitral Valve Prolapse I: Introduction

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IntroductionThe mitral valve, one of the heart's four valves, regulates blood flow. These valves have flaps that open and close to direct blood properly through the heart and body. During each heartbeat, the flaps open for blood to pass through and seal shut to prevent backflow. Specifically, the mitral valve opens to allow blood flow from the heart's upper left chamber to the lower left chamber. It then closes securely as the lower left chamber contracts to pump blood to the body, preventing...
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Mitral Stenosis III: Medical Management01:26

Mitral Stenosis III: Medical Management

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Mitral stenosis, a condition marked by the narrowing of the mitral valve, necessitates an integrated approach for effective management. This approach includes preventative measures, medical therapy, and surgical interventions to reduce symptoms and prevent complications.PreventionPrevention of mitral stenosis primarily focuses on reducing the incidence of bacterial infections, particularly streptococcal infections, which can lead to rheumatic fever and subsequent valvular damage. Timely...
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Development of the Heart01:27

Development of the Heart

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The development of the human heart, a crucial organ, commences from the mesoderm on the 18th or 19th day after fertilization. This process initiates in the cardiogenic area, a group of mesodermal cells at the embryo's head end, which evolves into elongated strands known as cardiogenic cords. These cords undergo a transformation to form hollow-centered endocardial tubes.
As the embryo undergoes lateral folding, these paired tubes approach each other, merging into a single primitive heart...
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Related Experiment Video

Updated: Aug 1, 2025

A Simplified Model for Heterotopic Heart Valve Transplantation in Rodents
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Growing Heart Valve Implants for Children.

Haley Konsek1, Curry Sherard1, Cora Bisbee1

  • 1Department of Surgery, College of Medicine, Medical University of South Carolina, Charleston, SC 29425, USA.

Journal of Cardiovascular Development and Disease
|April 27, 2023
PubMed
Summary

Pediatric heart valve replacements fail to grow with children. This review explores tissue-engineered valves and partial heart transplants as potential solutions for growing pediatric heart valves, addressing long-term clinical needs.

Keywords:
congenital heart diseasepartial heart transplanttissue-engineered heart valvevalve replacement

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Area of Science:

  • Biomedical Engineering
  • Regenerative Medicine
  • Pediatric Cardiology

Background:

  • Current heart valve implants for pediatric patients with congenital valvular disease do not accommodate somatic growth.
  • This limitation prevents long-term clinical success in children requiring valve replacement.
  • There is a critical need for pediatric heart valve solutions that can grow with the patient.

Purpose of the Study:

  • To review recent advancements in tissue-engineered heart valves (TEHVs) and partial heart transplantation.
  • To evaluate these approaches as potential growing heart valve implants for pediatric patients.
  • To discuss the barriers hindering clinical translation of these innovative therapies.

Main Methods:

  • Review of in vitro and in situ designs for tissue-engineered heart valves.
  • Analysis of large animal studies and clinical translational research.
  • Identification of challenges in the clinical application of growing heart valve technologies.

Main Results:

  • Tissue engineering and partial transplantation show promise as growing heart valve alternatives.
  • Significant progress has been made in designing and testing TEHVs.
  • Translational research in large animals provides a basis for clinical application.

Conclusions:

  • Tissue-engineered heart valves and partial heart transplantation represent promising avenues for pediatric growing heart valve solutions.
  • Overcoming barriers in design, manufacturing, and clinical integration is crucial for successful translation.
  • These regenerative approaches offer hope for improved long-term outcomes in children with congenital valvular disease.