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Tumor Immunotherapy01:27

Tumor Immunotherapy

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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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Stem Cell Therapy for Tissue Regeneration01:21

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Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
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Bone Marrow Sampling and Transplants01:22

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Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
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Targeted Cancer Therapies02:57

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
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Related Experiment Video

Updated: Aug 1, 2025

Generation of CAR T Cells for Adoptive Therapy in the Context of Glioblastoma Standard of Care
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Generation of CAR T Cells for Adoptive Therapy in the Context of Glioblastoma Standard of Care

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Adoptive Cell Therapy for Nonhematologic Solid Tumors.

Daniel J Olson1,2, Kunle Odunsi2,3

  • 1Department of Medicine, Section of Hematology/Oncology, University of Chicago, Chicago, IL.

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
|April 27, 2023
PubMed
Summary
This summary is machine-generated.

Adoptive cell therapy (ACT) shows promise for solid tumors where immunotherapy has failed. Advances in cell engineering and antigen identification are key to overcoming challenges and expanding ACT benefits for more patients.

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Area of Science:

  • Cancer Immunology
  • Cellular Therapy
  • Oncology

Background:

  • Immunotherapy benefits are limited in most nonhematologic solid tumors.
  • Adoptive cell therapy (ACT) involves isolating and engineering immune cells for cancer treatment.
  • Early clinical advances show ACT's potential in difficult-to-treat solid tumors.

Purpose of the Study:

  • To review major forms of Adoptive Cell Therapy (ACT).
  • To highlight successes of ACT in solid tumors.
  • To discuss strategies for overcoming current ACT limitations.

Main Methods:

  • Review of tumor-infiltrating lymphocyte therapy.
  • Analysis of engineered T-cell receptor and chimeric antigen receptor T-cell therapies.
  • Exploration of non-T-cell therapies like natural killer-cell therapy.

Main Results:

  • ACT, including tumor-infiltrating lymphocytes, shows activity in melanoma and cervical cancers.
  • Engineered T-cell therapies demonstrate potential against poorly immunogenic solid tumors.
  • Non-T-cell therapies may enable allogeneic forms of ACT.

Conclusions:

  • ACT offers potential for long-lasting responses in advanced nonhematologic solid tumors.
  • Key challenges include manufacturing, antigen identification, and toxicity.
  • Continued advancements in cancer immunology and cell engineering are crucial for expanding ACT's reach.