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Updated: Aug 1, 2025

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Published on: June 14, 2022
Cervids ACE2 Residues that Bind the Spike Protein can Provide Susceptibility to SARS-CoV-2
1Bioinformatics and Bio-Data Science Division, Health Informatics Department, Universidade Federal de São Paulo - UNIFESP, Rua Botucatu 862 - Prédio Leal Prado (térreo), São Paulo, SP, 04023-062, Brazil. luciano.lopes@unifesp.br.
Abstract:
The susceptibility of the white-tailed deer (WTD; Odocoileus virginianus) to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has highlighted cervids as coronavirus reservoirs. This study aimed to evaluate the angiotensin-converting enzyme 2 (ACE2) residues which bind the spike protein of SARS-CoV-2 from 16 cervids to predict their potential susceptibility to SARS-CoV-2 infection. Eleven out of 16 species presented identical ACE2 key residues to WTD ACE2. Four cervids presented K31N, a variant associated with low SARS-CoV-2 susceptibility. Large herding of cervids with ACE2 key residues identical to that of the WTD can result in extensive reservoirs of SARS-CoV-2. Cervids as potential reservoirs could favor SARS-CoV-2 adaptation and the emergence of new coronavirus strains.
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