Cardiac Magnetic Resonance Imaging Detects Myocardial Abnormalities in Naturally Infected Dogs with Chronic
Derek J Matthews1, Ryan C Fries2, Nicholas D Jeffery1
1Department of Small Animal Clinical Sciences, School of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX 77843-4474, USA.
Animals : an Open Access Journal From MDPI
|April 28, 2023
Summary
Cardiac magnetic resonance imaging (CMR) revealed common abnormalities in dogs with chronic Chagas disease. This study highlights CMR
Area of Science:
- Veterinary Cardiology
- Infectious Diseases
- Medical Imaging
Background:
- Trypanosoma cruzi infection leads to cardiac inflammation and fibrosis in dogs.
- Chronic Chagas disease in canines can result in significant cardiac damage.
Purpose of the Study:
- To characterize cardiac magnetic resonance imaging (CMR) findings in dogs with naturally occurring chronic Chagas disease.
- To determine the frequency of abnormalities detected by CMR and other cardiac diagnostic tests.
Main Methods:
- Ten asymptomatic, seropositive dogs underwent echocardiography, standard and ambulatory ECG, cardiac troponin I (cTnI) testing, and CMR.
- Data from various cardiac diagnostic modalities were compared to CMR findings.
Main Results:
- Ambulatory ECG showed more frequent abnormalities (6/10) than standard ECG.
- Echocardiography revealed abnormalities in 6/10 dogs, including decreased right ventricular systolic function.
- CMR detected abnormalities in 7/10 dogs, such as delayed myocardial enhancement, abnormal wall motion, and loss of apical compact myocardium.
Conclusions:
- CMR identified common cardiac abnormalities in dogs with T. cruzi infection.
- CMR provides valuable information for assessing cardiac involvement in canine Chagas disease.
- Naturally infected dogs may serve as a valuable animal model for Chagas disease research.
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