Related Experiment Video

Updated: Aug 1, 2025

Author Spotlight: Modeling an Aspect of Preeclampsia in Female Mice Using Hypoxic Human Placenta-Derived Small Extracellular Vesicles
05:31

Author Spotlight: Modeling an Aspect of Preeclampsia in Female Mice Using Hypoxic Human Placenta-Derived Small Extracellular Vesicles

Published on: January 26, 2024

878

Understanding the Role of Chemerin in the Pathophysiology of Pre-Eclampsia

Katarzyna Pankiewicz1, Tadeusz Issat1

  • 1Department of Obstetrics and Gynecology, Institute of Mother and Child in Warsaw, Kasprzaka 17a, 01-211 Warsaw, Poland.

Antioxidants (Basel, Switzerland)
|April 28, 2023
PubMed

Insights

Chemerin, an adipokine, is linked to cardiovascular diseases. Elevated chemerin levels in pre-eclampsia (PE) suggest its role in disease severity, particularly concerning oxidative stress and endothelial dysfunction.

Area of Science:

  • Biochemistry
  • Endocrinology
  • Pathophysiology

Background:

  • Chemerin is a multifunctional adipokine implicated in inflammation, adipogenesis, and energy metabolism.
  • Chemerin plays a significant role in the pathogenesis of various cardiovascular diseases.
  • Elevated blood chemerin levels and placental expression are observed in pre-eclampsia (PE) and correlate with disease severity.

Purpose of the Study:

  • To review the current understanding of chemerin's role in pre-eclampsia development.
  • To focus on chemerin's involvement in oxidative stress and endothelial dysfunction within PE.

Main Methods:

  • This is a narrative review.
  • Literature search on chemerin and pre-eclampsia.

Main Results:

  • Chemerin is implicated in multiple biological processes relevant to cardiovascular health.
  • Chemerin levels are elevated in pre-eclampsia patients.
  • Chemerin may contribute to PE through oxidative stress and endothelial dysfunction.

Conclusions:

  • Chemerin is a potential factor in pre-eclampsia pathogenesis.
  • Further research into chemerin's mechanisms in PE is warranted.
  • Targeting chemerin pathways could offer therapeutic strategies for PE.

Keywords:
chemerinendothelial dysfunctionoxidative stresspre-eclampsia

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