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Updated: Jun 26, 2026
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A Murine Model of Group B Streptococcus Vaginal Colonization
Published on: November 16, 2016
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Antimicrobial Photodynamic Inactivation: An Alternative for Group B Streptococcus Vaginal Colonization in a Murine
Michał K Pierański1, Jan G Kosiński2, Klaudia Szymczak1
1Laboratory of Photobiology and Molecular Diagnostics, Intercollegiate Faculty of Biotechnology University of Gdańsk and Medical University of Gdańsk, University of Gdańsk, 80-307 Gdańsk, Poland.
Antioxidants (Basel, Switzerland)
|April 28, 2023
Summary
Antimicrobial photodynamic inactivation (aPDI) effectively eliminates Group B Streptococcus (GBS) without harming beneficial vaginal flora or human cells. This non-antibiotic approach offers a safe alternative for treating GBS infections.
Area of Science:
- Microbiology
- Photomedicine
- Infectious Diseases
Background:
- Group B Streptococcus (GBS) causes severe neonatal infections.
- Antibiotic resistance necessitates alternative GBS treatments.
- Antimicrobial photodynamic inactivation (aPDI) is a promising non-antibiotic strategy.
Purpose of the Study:
- Evaluate rose bengal-mediated aPDI against GBS.
- Assess aPDI's safety and impact on vaginal microbiome.
Main Methods:
- Tested aPDI on GBS serotypes, Lactobacillus species, and human cells.
- Analyzed GBS viability in vitro and in vivo models.
- Evaluated effects on vaginal microbial flora composition.
Main Results:
- aPDI demonstrated high GBS killing efficacy (>4 log10 in vitro, ~2 log10 in vivo).
- RB-mediated aPDI showed no mutagenicity and was safe for human vaginal cells.
- aPDI preserved vaginal microbial flora balance and viability.
Conclusions:
- aPDI is an effective GBS killing method.
- aPDI presents a viable alternative for GBS vaginal colonization and infection treatment.
