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Nrf2 Protein Serum Concentration in Human CKD Shows a Biphasic Behavior
Marianne Rasmussen1, Kristian Horsman Hansen2, Alexandra Scholze1,3
1Department of Nephrology, Odense University Hospital, 5000 Odense C, Denmark.
Antioxidants (Basel, Switzerland)
|April 28, 2023
Summary
Nuclear factor erythroid 2-related factor 2 (Nrf2) protein increases in mild to moderate chronic kidney disease (CKD) but decreases in severe CKD. Understanding Nrf2 levels is crucial for developing targeted CKD therapies.
Area of Science:
- Nephrology
- Oxidative Stress Research
- Molecular Biology
Background:
- Oxidative stress is a key factor in chronic kidney disease (CKD) progression and mortality.
- Nuclear factor erythroid 2-related factor 2 (Nrf2) is a critical regulator of cellular redox balance.
- Nrf2-activating therapies are being investigated for various chronic diseases, including CKD.
Purpose of the Study:
- To investigate the behavior of Nrf2 protein levels in patients with varying stages of CKD.
- To determine the relationship between Nrf2 protein concentration and kidney function in CKD patients.
- To inform the development of Nrf2-targeted therapies for CKD.
Main Methods:
- Analysis of Nrf2 protein concentrations in CKD patients across different stages (G1-5) without renal replacement therapy.
- Comparison of Nrf2 levels between CKD patients and healthy subjects.
- Statistical analysis to assess the correlation between Nrf2 protein concentration and estimated glomerular filtration rate (eGFR).
Main Results:
- Nrf2 protein levels were upregulated in patients with mild to moderate CKD (G1-3) compared to healthy controls.
- A significant positive correlation was observed between Nrf2 protein concentration and kidney function (eGFR) within the CKD population.
- Nrf2 protein levels were reduced in severe CKD (G4-5) compared to mild to moderate CKD.
Conclusions:
- Nrf2 protein concentration increases in mild to moderate CKD but decreases in severe CKD.
- The findings highlight a dynamic change in Nrf2 levels as CKD progresses.
- Further research is needed to identify specific CKD patient populations that would benefit most from Nrf2-targeted therapies.
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