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Published on: December 4, 2013
Paraoxonases at the Heart of Neurological Disorders
Fatimah K Khalaf1,2, Jacob Connolly1, Bella Khatib-Shahidi1
1Department of Medicine, University of Toledo College of Medicine and Life Sciences, Toledo, OH 43606, USA.
Abstract:
Paraoxonase enzymes serve as an important physiological redox system that participates in the protection against cellular injury caused by oxidative stress. The PON enzymes family consists of three members (PON-1, PON-2, and PON-3) that share a similar structure and location as a cluster on human chromosome 7. These enzymes exhibit anti-inflammatory and antioxidant properties with well-described roles in preventing cardiovascular disease. Perturbations in PON enzyme levels and their activity have also been linked with the development and progression of many neurological disorders and neurodegenerative diseases. The current review summarizes the available evidence on the role of PONs in these diseases and their ability to modify risk factors for neurological disorders. We present the current findings on the role of PONs in Alzheimer's disease, Parkinson's disease, and other neurodegenerative and neurological diseases.
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