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Updated: Aug 1, 2025

An Orthotopic Murine Model of Human Prostate Cancer Metastasis
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Sulforaphane and Its Protective Role in Prostate Cancer: A Mechanistic Approach

James Mordecai1, Saleem Ullah2, Irshad Ahmad1,3

  • 1Department of Bioengineering, King Fahd University of Petroleum and Minerals (KFUPM), Dhahran 31261, Saudi Arabia.

International Journal of Molecular Sciences
|April 28, 2023
PubMed

Insights

Sulforaphane, a compound from broccoli, shows promise in preventing prostate cancer progression. This review covers its anticancer effects and mechanisms in various settings, offering insights for future therapeutic use.

Area of Science:

  • Oncology
  • Nutritional Science
  • Phytochemistry

Background:

  • Prostate cancer incidence is rising globally.
  • Sulforaphane, a phytochemical from Brassica vegetables, exhibits anticancer properties.
  • Existing research indicates sulforaphane's potential in preventing prostate tumor development and progression.

Purpose of the Study:

  • To review recent findings on sulforaphane's role in preventing prostate cancer progression.
  • To detail the proposed mechanisms of action of sulforaphane.
  • To discuss challenges and future prospects for sulforaphane as a prostate cancer therapeutic.

Main Methods:

  • In vitro studies
  • In vivo studies
  • Clinical trials
  • Literature review of recent publications

Main Results:

  • Sulforaphane demonstrates efficacy in preventing prostate cancer progression across in vitro, in vivo, and clinical models.
  • Multiple mechanisms of action are proposed for sulforaphane's effects on prostate cells.
  • Evidence supports sulforaphane's potential as a preventative and therapeutic agent.

Conclusions:

  • Sulforaphane is a promising agent for prostate cancer prevention and treatment.
  • Further research is needed to overcome challenges and optimize its therapeutic application.
  • Future prospects include integrating sulforaphane into prostate cancer management strategies.
Keywords:
broccolicancer therapeuticscell cyclegreen chemopreventionmyrosinaseprostate cancersulforaphane

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