Improved Simulated-Daylight Photodynamic Therapy and Possible Mechanism of Ag-Modified TiO₂ on Melanoma

Simulated-daylight photodynamic therapy (SD-PDT) may be an efficacious strategy for treating melanoma because it can overcome the severe stinging pain, erythema, and edema experienced during conventional PDT. However, the poor daylight response of existing common photosensitizers leads to unsatisfactory anti-tumor therapeutic effects and limits the development of daylight PDT. Hence, in this study, we utilized Ag nanoparticles to adjust the daylight response of TiO₂, acquire efficient photochemical activity, and then enhance the anti-tumor therapeutic effect of SD-PDT on melanoma. The synthesized Ag-doped TiO₂ showed an optimal enhanced effect compared to Ag-core TiO₂. Doping Ag into TiO₂ produced a new shallow acceptor impurity level in the energy band structure, which expanded optical absorption in the range of 400-800 nm, and finally improved the photodamage effect of TiO₂ under SD irradiation. Plasmonic near-field distributions were enhanced due to the high refractive index of TiO₂ at the Ag-TiO₂ interface, and then the amount of light captured by TiO₂ was increased to induce the enhanced SD-PDT effect of Ag-core TiO₂. Hence, Ag could effectively improve the photochemical activity and SD-PDT effect of TiO₂ through the change in the energy band structure. Generally, Ag-doped TiO₂ is a promising photosensitizer agent for treating melanoma via SD-PDT.