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Updated: Aug 1, 2025
08:07
Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma
Published on: April 12, 2019
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Osteosarcoma: Current Concepts and Evolutions in Management Principles
Pampina Pilavaki1,2, Amir Gahanbani Ardakani3, Panagiotis Gikas3
1Medical School, University of Cyprus, Nicosia 1678, Cyprus.
Journal of Clinical Medicine
|April 28, 2023
Summary
Osteosarcoma, a rare bone cancer, presents treatment challenges. This review explores new therapies like immunotherapy and targeted drugs to improve outcomes for patients with recurrent or metastatic osteosarcoma.
Area of Science:
- Oncology
- Orthopedic Oncology
- Cancer Therapeutics
Background:
- Osteosarcoma is the most common bone sarcoma, originating from mesenchymal tissue.
- Current treatments (surgery, radiotherapy, chemotherapy) have limitations, with frequent recurrence and poor prognosis for metastatic disease.
- Novel therapeutic strategies are urgently needed to improve osteosarcoma patient survival.
Purpose of the Study:
- To review recent advances in osteosarcoma management.
- To discuss emerging therapeutic options including immunotherapy and targeted therapies.
- To highlight the need for further research into novel treatment modalities.
Main Methods:
- Review of recent literature on osteosarcoma therapeutic management.
- Discussion of surgical and medical treatment advancements.
- Exploration of immunotherapy (immune checkpoint inhibitors, adoptive cellular therapy, cancer vaccines) and targeted therapies (tyrosine kinase inhibitors).
Main Results:
- Significant advances in surgical and medical management of osteosarcoma are emerging.
- Immunotherapy and targeted therapies show promise but require further investigation.
- Current treatment paradigms face challenges with disease recurrence and metastasis.
Conclusions:
- Novel therapeutic strategies are crucial for improving osteosarcoma outcomes.
- Immunotherapy and targeted therapies represent promising avenues for future treatment.
- Additional research is essential to define the clinical roles of these advanced therapies.
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