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Acquired Angioedema in Selected Neoplastic Diseases
Magdalena Zając1, Andrzej Bożek1, Renata Kozłowska1
1Clinical Department of Internal Diseases, Dermatology and Allergology, Medical University of Silesia, 40-055 Katowice, Poland.
Medicina (Kaunas, Lithuania)
|April 28, 2023
Summary
Acquired angioedema with C1 inhibitor deficiency (C1-INH-AAE) is more common in cancer patients, particularly those with early-stage breast cancer. This finding highlights a potential link between neoplastic diseases and this rare angioedema subtype.
Area of Science:
- Oncology
- Immunology
- Dermatology
Background:
- Acquired angioedema is a recognized complication of various systemic diseases, including autoimmune disorders and malignancies.
- C1-INH-AAE, a specific subtype, warrants further investigation regarding its association with cancer.
Purpose of the Study:
- To determine the incidence of C1-INH-AAE in patients diagnosed with breast, colorectal, or lung cancer.
- To explore the relationship between C1-INH-AAE and cancer stage, type, and specific genetic mutations.
Main Methods:
- Retrospective analysis of 1,312 cancer patients (723 women, 589 men; mean age 58.2 years).
- Data collection included cancer diagnosis (ICD-10), TNM staging, histopathology, and C1-INH-AAE occurrence.
- Comparison with a control group to assess incidence rates.
Main Results:
- C1-INH-AAE was significantly more prevalent in cancer patients (29%) compared to controls (6%) (p < 0.05).
- Breast cancer patients exhibited the highest incidence of C1-INH-AAE (37%), followed by colorectal (26%) and lung cancer (16%) (p < 0.05).
- Early-stage breast cancer showed a higher incidence of C1-INH-AAE; no association found with BRCA1/2 mutations or histopathology.
Conclusions:
- C1-INH-AAE occurs more frequently in patients with specific cancers, notably early-stage breast cancer.
- The findings suggest a potential clinical association between C1-INH-AAE and neoplastic diseases.
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