Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Plasma volume and proteins in voluntary hyperventilation.

M Stäubli, F Rohner, P Kammer

    Journal of Applied Physiology (Bethesda, Md. : 1985)
    |May 1, 1986
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Dosimetric Comparison Between Helical Tomotherapy and Volumetric Modulated Arc Therapy in Patients With Malignant Pleural Mesothelioma.

    Clinical oncology (Royal College of Radiologists (Great Britain))·2021
    Same author

    Validation of the Munich Swallowing Score (MUCSS) in patients with neurogenic dysphagia: A preliminary study.

    NeuroRehabilitation·2021
    Same author

    Controlling the Self-Injection Threshold in Laser Wakefield Accelerators.

    Physical review letters·2018
    Same author

    TIMP3 is Regulated by Pericytes upon Shear Stress Detection Leading to a Modified Endothelial Cell Response.

    European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery·2017
    Same author

    Subcortical Contributions to Motor Speech: Phylogenetic, Developmental, Clinical.

    Trends in neurosciences·2017
    Same author

    Above-ground biomass and structure of pristine Siberian Scots pine forests as controlled by competition and fire.

    Oecologia·2017

    Voluntary hyperventilation (HV) in splenectomized individuals caused a rapid, reversible loss of protein-free fluid from the vascular space. This fluid shift also affected red blood cells, but the spleen did not contribute to observed hematocrit changes.

    Area of Science:

    • Physiology
    • Cardiovascular System
    • Fluid Dynamics

    Background:

    • Understanding fluid shifts and protein dynamics during physiological stress is crucial.
    • The role of the spleen in regulating red blood cell volume and plasma dynamics requires further investigation.
    • Voluntary hyperventilation (HV) is known to induce physiological changes, but its precise impact on plasma volume and protein distribution is not fully elucidated.

    Purpose of the Study:

    • To investigate the effects of voluntary hyperventilation (HV) on plasma volume and plasma protein concentrations.
    • To determine if HV induces a significant loss of intravascular proteins.
    • To assess the involvement of the red cell compartment and splenic function in HV-induced fluid shifts.

    Main Methods:

    • Controlled study involving nine splenectomized volunteers.

    Related Experiment Videos

  • Measurement of plasma volume changes using hemoglobin and hematocrit.
  • Monitoring of plasma epinephrine and norepinephrine levels during HV.
  • Comparison of HV conditions with a control study (rest in supine position).

    • Main Results:

    • Twenty minutes of HV led to a 12.9% reduction in plasma volume.
    • Intravascular protein masses (total protein, albumin) decreased, but similarly in control conditions, indicating no significant protein loss due to HV.
    • Mean red cell volume decreased by 2.2% (P < 0.02) compared to controls.
    • HV induced a rapid, reversible loss of a virtually protein-free solution from the vascular space.

    Conclusions:

    • Acute voluntary hyperventilation causes a rapid and reversible loss of protein-free fluid from the vascular space.
    • The observed decrease in red cell volume suggests participation in fluid shifts.
    • Splenic erythrocyte contribution is not a factor in HV-induced hemoglobin and hematocrit changes.