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Updated: Aug 1, 2025
11:17
Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
Published on: August 30, 2018
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Multidrug Resistance in Critically Ill Patients: An Unresolved Issue
1Intensive Care Unit, Department of Translational Medicine, University of Ferrara, 44121 Ferrara, Italy.
Microorganisms
|April 28, 2023
Summary
Early antimicrobial therapy within one hour is vital for sepsis and septic shock patients. Optimizing drug dosing in intensive care units (ICUs) is crucial due to changing patient pharmacokinetics.
Area of Science:
- Critical care medicine
- Infectious diseases
- Clinical pharmacology
Background:
- Sepsis and septic shock necessitate prompt, effective antimicrobial treatment.
- The Surviving Sepsis Campaign (SSC) guidelines emphasize initiating therapy within the first hour.
- Altered pharmacokinetics in critically ill patients complicate antimicrobial efficacy.
Discussion:
- Optimizing antimicrobial drug dosing in intensive care units (ICUs) is essential.
- Drug administration must ensure coverage of probable pathogens and adequate concentrations.
- Continuous monitoring and adjustment of therapy are needed due to dynamic patient conditions.
Key Insights:
- Early empiric antimicrobial therapy is a cornerstone in managing sepsis and septic shock.
- Pharmacokinetic variability in critically ill patients requires individualized dosing strategies.
- Effective management hinges on timely, appropriate antimicrobial administration and dose optimization.
Outlook:
- Future research should focus on advanced pharmacokinetic/pharmacodynamic (PK/PD) modeling for precise dosing.
- Innovations in diagnostics and targeted therapies are needed for multidrug-resistant (MDR) infections.
- This Special Issue explores epidemiology, diagnostics, and management strategies for MDR infections in critically ill patients.
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