Rapid Elution of ²²⁶Th from a Two-Column ²³⁰U/²²⁶Th Generator with Diluted and Buffer Solutions

A radionuclide generator of the short-lived alpha emitter ²²⁶Th was proposed. An original scheme consisting of two in-series chromatographic columns was developed for rapidly producing a neutral citric-buffered eluate of high purity ²²⁶Th. The first column filled with TEVA resin retained the parent ²³⁰U, while ²²⁶Th was eluted with 7 M HCl solution to be immediately adsorbed on the second column containing DGA resin or UTEVA resin. Having substituted the strongly acidic medium of second column with neutral salt solution, ²²⁶Th was desorbed with diluted citric buffer solution. One cycle of generator milking took 5-7 min and produced >90% of ²²⁶Th in 1.5 mL of eluate (pH 4.5-5.0) appropriate for direct use in radiopharmaceutical synthesis. The ²³⁰U impurity in ²²⁶Th eluate was less than 0.01%. The proposed two-column ²³⁰U/²²⁶Th generator was tested over 2 months including a second loading of ²³⁰U additionally accumulated from ²³⁰Pa.