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Kidney and urinary tract involvement in systemic mastocytosis
Joyita Bharati1, Nikita Shah2, Ankuri Desai3
1Division of Kidney Diseases and Hypertension, Glomerular Center at Northwell Health, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Great Neck, NY, USA.
Summary
Systemic mastocytosis (SM) rarely directly affects kidneys but can cause indirect kidney injury. Treatments and associated conditions like glomerulonephritis contribute to kidney dysfunction in SM patients.
Area of Science:
- Nephrology
- Hematology
- Oncology
Background:
- Systemic mastocytosis (SM) involves abnormal mast cell accumulation.
- KIT gene mutations are common drivers of SM.
- Kidney involvement in SM is typically indirect.
Approach:
- This narrative review synthesizes current literature on kidney involvement in SM.
- It examines direct and indirect mechanisms of renal injury.
- The review discusses SM-associated glomerulonephritis and drug-induced kidney dysfunction.
Key Points:
- SM can lead to kidney dysfunction through various mechanisms.
- Novel anti-neoplastic agents may cause kidney injury.
- Immune-mediated glomerulonephritis is a recognized complication.
- Monoclonal deposition disease and amyloidosis are linked to SM with plasma cell dyscrasia.
Conclusions:
- Kidney involvement is an important consideration in managing systemic mastocytosis.
- Understanding these associations is crucial for patient care and treatment strategies.
Keywords:
glomerulonephritiskidneyparaproteinsystemic mastocytosistubulo-interstitial nephritistyrosine kinase inhibitorMore Related Videos
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