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Tissue Factor and Vascular Endothelial Growth Factor in Detecting Thromboembolic Complications in Diabetic

Tijen Alkan Bozkaya1,2,3, Şanser Ateş1, Ünsal Veli Üstündağ4

  • 1Department of Cardiovascular Surgery, Koç University Hospital, Istanbul, Turkey.

Clinical Medicine Insights. Circulatory, Respiratory and Pulmonary Medicine
|April 28, 2023
PubMed

Insights

Tissue factor (TF) and vascular endothelial growth factor-A (VEGF-A) are elevated in diabetic atherosclerosis patients, indicating potential for early detection of thromboembolic complications. These markers correlate with longer hospital stays and increased risk factors.

Area of Science:

  • Cardiovascular Medicine
  • Endocrinology
  • Biochemistry

Background:

  • Atherosclerosis is a leading global cause of death, with diabetes exacerbating thromboembolic complications.
  • The precise mechanisms of endothelial damage in diabetic atherosclerosis remain unclear.
  • Understanding these mechanisms is crucial for managing cardiovascular risk in diabetic patients.

Purpose of the Study:

  • To investigate the role of tissue factor (TF) and vascular endothelial growth factor-A (VEGF-A) in diabetic atherosclerosis.
  • To assess TF and VEGF-A as potential indicators of thromboembolic complications in diabetic patients undergoing coronary artery bypass surgery.
  • To analyze the correlation between these markers, patient demographics, and postoperative outcomes.

Main Methods:

  • A cohort of 100 patients undergoing off-pump coronary artery bypass (OPCAB) were divided into diabetic and non-diabetic groups.
  • Preoperative and postoperative levels of TF and VEGF-A were measured.
  • Early postoperative outcomes, hospital stay, and carotid intima-media thickness (CT) were analyzed.

Main Results:

  • Diabetic patients exhibited statistically significant higher levels of TF and VEGF-A compared to non-diabetics.
  • Elevated TF and VEGF-A levels correlated with significantly longer hospital stays in the diabetic group.
  • Higher preoperative CT in diabetics was significantly associated with atrial fibrillation (AF).

Conclusions:

  • TF and VEGF-A levels may serve as important early indicators for thromboembolic complications in patients with diabetic atherosclerosis.
  • These findings highlight the potential of TF and VEGF-A in risk stratification and early detection.
  • Further research can elucidate the precise role of these markers in the pathogenesis of diabetic cardiovascular disease.
Abstract

Keywords:
atherosclerosisatrial fibrillationdiabetestissue factorvascular endothelial growth factor

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