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Related Experiment Videos

Plasma norepinephrine in exercise-induced ventricular tachycardia.

N M Sokoloff, S R Spielman, A M Greenspan

    Journal of the American College of Cardiology
    |July 1, 1986
    PubMed
    Summary

    Plasma norepinephrine levels do not predict exercise-induced ventricular tachycardia. However, beta-adrenergic blockade with propranolol effectively prevents this arrhythmia, correlating with reduced norepinephrine levels.

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    Area of Science:

    • Cardiology
    • Exercise Physiology

    Background:

    • Exercise testing can provoke ventricular tachycardia (VT).
    • The role of plasma norepinephrine in exercise-induced VT is not fully understood.

    Purpose of the Study:

    • To investigate the relationship between plasma norepinephrine levels and exercise-induced VT.
    • To assess the efficacy of beta-adrenergic blockade in preventing exercise-induced VT.

    Main Methods:

    • Prospective evaluation of 17 patients undergoing exercise testing.
    • Measurement of plasma norepinephrine levels at rest, peak exercise, and recovery.
    • Repeat exercise testing after beta-adrenergic blockade with propranolol in patients with VT.

    Main Results:

    • No significant difference in plasma norepinephrine levels between patients with and without exercise-induced VT.

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  • Exercise-induced VT did not occur in 90% of patients after propranolol administration.
  • Propranolol significantly decreased plasma norepinephrine levels.

    • Conclusions:

    • Plasma norepinephrine levels do not reliably identify patients at risk for exercise-induced VT.
    • Beta-adrenergic blockade with propranolol is effective in suppressing exercise-induced VT.
    • The antiarrhythmic effect of propranolol is associated with reduced norepinephrine levels.