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Updated: Aug 1, 2025

Accessing the Cytotoxicity and Cell Response to Biomaterials

Accessing the Cytotoxicity and Cell Response to Biomaterials

Published on: July 8, 2021

Biomaterials That Induce Immunogenic Cell Death.

Di Li^1,2, Siqi Liu², Yang Ma^2,3

¹Department of Hepatobiliary and Pancreatic Surgery, General Surgery Center, The First Hospital of Jilin University, 1 Xinmin Street, Changchun, 130061, P. R. China.

|April 28, 2023

Summary

This summary is machine-generated.

Biomaterials can induce immunogenic cell death (ICD) in tumor cells, activating immune responses for cancer immunotherapy. This review covers ICD-inducing biomaterials and their clinical potential.

Keywords:

biomaterials cell membrane rupture endoplasmic reticulum oxidative stress immunogenic cell death mitochondrial dysfunction

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Area of Science:

Biomaterials science
Immunology
Oncology

Background:

The immune system plays a critical role in cancer development and progression.
Cancer immunotherapy offers a promising treatment strategy.
Immunogenic cell death (ICD) is a key process in activating anti-tumor immune responses.

Purpose of the Study:

To review the progress of biomaterials designed to induce immunogenic cell death (ICD) in cancer cells.
To discuss the mechanisms by which these biomaterials trigger ICD.
To explore the clinical application prospects of ICD-inducing biomaterials in cancer immunotherapy.

Main Methods:

Summary of research on biomaterials that induce ICD.
Analysis of mechanisms including endoplasmic reticulum oxidative stress, mitochondrial dysfunction, and cell membrane rupture.
Discussion of clinical translation potential.

Main Results:

Biomaterials are emerging as effective agents for inducing ICD.
ICD induction by biomaterials involves specific cellular stress pathways.
These biomaterials offer biosafety and functional modification advantages.

Conclusions:

ICD-inducing biomaterials represent a promising approach for cancer immunotherapy.
Further research and clinical trials are needed to realize their full potential.
Biomaterials offer a versatile platform for enhancing anti-tumor immunity.