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Area of Science:

  • Electrochemistry
  • Materials Science
  • Nanotechnology

Background:

  • Developing high-efficiency electrocatalysts for sensitive electrochemical sensing is a significant challenge.
  • Single-atom catalysts offer unique properties for enhanced catalytic activity.

Purpose of the Study:

  • To prepare and characterize single-atom indium anchored on nitrogen-doped carbon (In1-N-C) with an In-N4 configuration.
  • To evaluate its performance as an electrocatalyst for sensitive electrochemical sensing of dopamine (DA).
  • To explore its potential for simultaneous detection of multiple biomolecules.

Main Methods:

  • High-temperature annealing strategy for synthesizing In1-N-C.
  • Electrochemical characterization and sensing of dopamine.
  • Theoretical calculations (DFT) to understand reaction mechanisms.
  • Simultaneous detection assays for uric acid, ascorbic acid, and DA.

Main Results:

  • Successfully synthesized In1-N-C with atomically dispersed In-N4 sites.
  • In1-N-C demonstrated significantly higher catalytic performance for DA oxidation compared to indium nanoparticles.
  • Theoretical calculations confirmed enhanced intrinsic activity of In1-N-C due to favorable adsorption and low energy barriers.
  • Developed a concept electrochemical sensor for DA with high sensitivity and selectivity.
  • Validated the catalyst for simultaneous detection of uric acid, ascorbic acid, and DA.

Conclusions:

  • Atomically dispersed In-N4 sites in In1-N-C provide enhanced intrinsic activity for electrocatalysis.
  • In1-N-C is a promising advanced electrocatalyst for sensitive and selective electrochemical sensing of dopamine.
  • This work broadens the application of p-block metal single-atom catalysts in electrochemical sensing.