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Pain-causing stinging nettle toxins target TMEM233 to modulate NaV1.7 function.

Sina Jami1, Jennifer R Deuis1, Tabea Klasfauseweh1

  • 1Institute for Molecular Bioscience, The University of Queensland, St Lucia, QLD, 4072, Australia.

Nature Communications
|April 28, 2023
PubMed
Summary

The transmembrane protein TMEM233 is essential for the pain toxin Excelsatoxin A to affect voltage-gated sodium channels (NaV). Co-expression of TMEM233 modifies NaV1.7 channel gating, revealing its role as an accessory protein.

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