Induced volatolomics of pathologies.

Area of Science:

• Biochemistry
• Analytical Chemistry
• Medical Diagnostics

Background:

• Volatolomics analyzes volatile organic compounds (VOCs) for real-time metabolic insights.
• Endogenous VOCs can serve as disease biomarkers, but interlaboratory variability and interindividual differences limit their diagnostic utility.
• Induced volatolomics offers a novel approach to overcome these limitations.

Purpose of the Study:

• To review the application of volatile-compound-based probes in induced volatolomics.
• To discuss the potential of these probes for diagnosing and monitoring diseases, including infections and cancers.
• To explore the use of probes in assessing organ function and understanding biological processes.

Main Methods:

• Focus on exogenous biological or chemical probes metabolized into VOCs.
• Analysis of VOCs resulting from pathogen-specific or metabolic-specific enzymatic activity.
• Review of studies utilizing labeled probes to track metabolic processes.

Main Results:

• Volatile-compound-based probes can detect and discriminate pathogenic infections.
• Probes show potential for real-time diagnosis and monitoring of cancers.
• Applications extend to assessing organ function and general biological exploration.

Conclusions:

• Induced volatolomics with volatile-compound-based probes offers a promising avenue for enhanced diagnostics.
• Labeled probes provide valuable insights into metabolic processes.
• Further investigation and clinical trials are warranted to fully realize the potential of this technology.