Related Experiment Video
Updated: Aug 1, 2025

Versatile CO2 Transformations into Complex Products: A One-pot Two-step Strategy
Published on: November 9, 2019
Bifunctional reagents in organic synthesis
Huan-Ming Huang1, Peter Bellotti1, Jiajia Ma1
1Organisch-Chemisches Institut, Westfälische Wilhelms-Universität Münster, Münster, Germany.
Abstract:
Developments in synthetic chemistry are increasingly driven by improvements in the selectivity and sustainability of transformations. Bifunctional reagents, either as dual coupling partners or as a coupling partner in combination with an activating species, offer an atom-economic approach to chemical complexity, while suppressing the formation of waste. These reagents are employed in organic synthesis thanks to their ability to form complex organic architectures and empower novel reaction pathways. This Review describes several key bifunctional reagents by showcasing selected cornerstone research areas and examples, including radical reactions, C-H functionalization, cross-coupling, organocatalysis and cyclization reactions.
More Related Videos
Related Concept Videos
Prochirality
Regioselectivity and Stereochemistry of Hydroboration
Hydroboration proceeds in a concerted fashion with the attack of borane on the π bond, giving a cyclic four-centered transition state. The –BH2 group is bonded to the less substituted carbon and –H to the more substituted carbon. The concerted nature requires the simultaneous addition of –H and –BH2 across the same face of the alkene giving syn...
Cycloaddition Reactions: Overview
Preparation of 1° Amines: Hofmann and Curtius Rearrangement Overview
Hydroboration-Oxidation of Alkenes
Diels–Alder Reaction Forming Bridged Bicyclic Products: Stereochemistry

