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Related Concept Videos

Tumor Immunotherapy01:27

Tumor Immunotherapy

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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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Updated: Aug 1, 2025

Experimental Melanoma Immunotherapy Model Using Tumor Vaccination with a Hematopoietic Cytokine
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Surface-Engineered Monocyte Immunotherapy Combined Graphene Quantum Dots Effective Against Solid Tumor Targets.

Qing Xia1, Yue Tang1, Wang Li1

  • 1School of Pharmacy and Bioengineering, Chongqing University of Technology, Chongqing, People's Republic of China.

International Journal of Nanomedicine
|May 1, 2023
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Summary

This study engineered monocytes with graphene quantum dots and microRNA155 to overcome the immunosuppressive tumor microenvironment. This novel immunotherapy reprogrammed tumor-associated macrophages, enhancing anti-tumor immunity and showing potential for solid tumor treatment.

Keywords:
GQDsimmunotherapymiR155solid tumorsurface-engineered monocyte

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Area of Science:

  • Immunology
  • Nanotechnology
  • Oncology

Background:

  • The immunosuppressive tumor microenvironment (TME) hinders drug delivery and T cell function in solid tumors.
  • Overcoming immune suppression is crucial for effective cancer immunotherapy.

Purpose of the Study:

  • To develop a novel therapeutic strategy to enhance cancer immunotherapy.
  • To engineer monocytes with graphene quantum dots (GQDs) and microRNA155 (miR) for targeted cancer treatment.

Main Methods:

  • Conjugation of miR to therapeutic monocytes decorated with GQDs.
  • Utilizing surface-engineered monocyte immunotherapy to reverse TME.
  • Reprogramming pro-tumoral M2 tumor-associated macrophages (TAMs) into antitumor M1 macrophages.

Main Results:

  • Surface-engineered monocytes effectively reversed the immunosuppressive TME.
  • Reprogramming of M2 TAMs to M1 TAMs was achieved, enhancing anti-tumor immunity.
  • Tumor elimination was dramatically improved.

Conclusions:

  • Surface-engineered monocyte immunotherapy is well-tolerated and biocompatible.
  • This strategy shows significant potential for treating solid tumors.
  • Further development for clinical application is warranted.