Related Experiment Video
Updated: Aug 1, 2025
06:43
Quantitative Analysis and Characterization of Atherosclerotic Lesions in the Murine Aortic Sinus
Published on: December 7, 2013
13.8K
Molecular imaging research in atherosclerosis: A 23-year scientometric and visual analysis
Juhong Pan1, Yueying Chen1, Yugang Hu1
1Department of Ultrasound Imaging, Renmin Hospital of Wuhan University, Wuhan, China.
Frontiers in Bioengineering and Biotechnology
|May 1, 2023
Summary
Molecular imaging shows promise for early atherosclerosis detection and treatment. This scientometric analysis reveals key research trends, including nanoparticles and positron emission tomography, highlighting future directions for cardiovascular disease research.
Area of Science:
- Cardiovascular Research
- Medical Imaging
- Bibliometrics
Background:
- Atherosclerosis is a primary cause of global cardiovascular and cerebrovascular diseases.
- Molecular imaging offers significant potential for early diagnosis and targeted therapy of atherosclerosis.
- This study analyzes 23 years of research to map progress, hotspots, and trends in this field.
Approach:
- A scientometric analysis of 1755 publications from 59 countries (1999-2022) was performed.
- Data was retrieved from the Web of Science Core Collection.
- Visualization tools (CiteSpace, VOSviewer) analyzed collaborations, co-citations, and keyword co-occurrence.
Key Points:
- The United States leads research output, with Harvard University and Dr. Fayad, ZA as highly productive.
- Top journals include CIRCULATION and ARTERIOSCL THROM VAS.
- Key research clusters identified: nanoparticles, MRI, inflammation, PET, and ultrasonography.
- Hot topics: cardiovascular disease, contrast media, macrophages, vulnerable plaque, microbubbles.
- Emerging trends: Sodium fluoride-PET, targeted drug delivery, OCT, photoacoustic imaging, ROS, and oxidative stress.
Conclusions:
- Molecular imaging research in atherosclerosis is a rapidly growing academic area.
- Challenges remain in translating these advancements into clinical practice.
- Findings provide insights for future research funding and strategic directions in atherosclerosis imaging.
Related Concept Videos
01:20Imaging Studies for Cardiovascular System III: X-Ray
221
The most common cardiovascular diagnostic test is an X-ray. It produces images of the heart, blood vessels, and adjacent structures.
Definition and Purpose
An X-ray, or radiograph, is a non-invasive method that uses ionizing radiation to take images of internal structures. It is mainly used in cardiac imaging to examine the heart, lungs, and major blood vessels, aiming to identify abnormalities in the heart's size, shape, and position, such as heart failure, congenital defects, and vascular...
Definition and Purpose
An X-ray, or radiograph, is a non-invasive method that uses ionizing radiation to take images of internal structures. It is mainly used in cardiac imaging to examine the heart, lungs, and major blood vessels, aiming to identify abnormalities in the heart's size, shape, and position, such as heart failure, congenital defects, and vascular...
221
01:19Imaging Studies VII: Vascular Imaging
36
DefinitionRenal angiography, also known as renal arteriography, is an imaging technique used to obtain a comprehensive view of blood flow and the vascular structure of blood vessels in the kidneys and surrounding areas.PurposeRenal angiography detects blood vessel abnormalities in the kidneys, such as aneurysms, stenosis, thrombosis, vascular tumors, and renal artery stenosis. It evaluates kidney function and guides interventional treatments like angioplasty or stent placement.Pre-Procedure...
36
01:21Imaging Studies for Cardiovascular System IV: CMRI
66
Cardiovascular magnetic resonance imaging, or CMRI, is a non-invasive diagnostic test that employs a magnetic field and radiofrequency waves to create precise images of the heart and arteries. It provides comprehensive information about cardiac anatomy, function, perfusion, and tissue characterization without ionizing radiation.IndicationsCMRI diagnoses various heart conditions, including tissue damage from heart attacks, ischemic heart disease, myocarditis, aortic issues (tears, aneurysms,...
66
01:27Atherosclerosis II: Clinical Manifestations and Diagnostic Tests
19
Atherosclerosis is a progressive disorder that leads to the thickening and narrowing of arterial walls due to plaque buildup. This condition can cause various symptoms depending on the arteries affected:Coronary Artery Disease (CAD): This condition affects the coronary arteries and may lead to chest pain (angina), shortness of breath (dyspnea), heart attacks, and other heart disease symptoms.Cerebrovascular Disease: This affects blood flow to the brain, causing transient ischemic attacks (TIAs)...
19
01:28Imaging Studies for Cardiovascular System V: CT
48
Cardiac computed tomography (CT) scanning is an advanced cardiac imaging technique that utilizes CT technology, with or without intravenous (IV) contrast, to produce accurate cross-sectional virtual slices of specific areas of the heart, coronary circulation, and major blood vessels such as the aorta, pulmonary veins, and arteries. The computer processes these slices to generate three-dimensional images. Multidetector CT (MDCT) is a rapid form of CT scanning that captures multiple slices...
48
01:30Atherosclerosis I: Introduction
18
Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
18