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Updated: Jul 31, 2025

Synthesis of a Borylated Ibuprofen Derivative Through Suzuki Cross-Coupling and Alkene Boracarboxylation Reactions
Published on: November 30, 2022
Automated, Capsule-Based Suzuki-Miyaura Cross Couplings
Guillaume Coin1,2, Tuo Jiang1, Samuele Bordi1
1Synple Chem AG, Kemptpark 18, 8310 Kemptthal, Switzerland.
Abstract:
The development of an automated process for Suzuki-Miyaura cross couplings is described, in which the complete reaction, workup, and product isolation are effected automatically with no user involvement, aside from loading of the starting materials and reaction capsule. This practical and simple method was successfully demonstrated to provide the desired biaryl products using a range of aryl bromides and boronic acids and is also effective for the late-stage functionalization of aryl halides in bioactive molecules.
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