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Programmable Electrochemical Stimulation on a Large-Scale CMOS Microelectrode Array.

Pushkaraj S Joshi1, Kangping Hu1, Joseph W Larkin2

  • 1Brown University, Providence, RI, USA.

IEEE Biomedical Circuits and Systems Conference : Healthcare Technology : [Proceedings]. IEEE Biomedical Circuits and Systems Conference
|May 1, 2023
PubMed
Summary
This summary is machine-generated.

This study introduces precise electrochemical control over aqueous samples using a high-pixel microelectrode array. Researchers achieved programmable electrodeposition, controlled electrolysis for hydrogen bubble generation, and targeted pH changes for bioelectronics.

Keywords:
Microelectrode arraybubble formationelectrolysispH controlstimulation

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Area of Science:

  • Bioelectronics
  • Electrochemistry
  • Materials Science

Background:

  • Precise control over electrochemical processes at the microscale is crucial for advanced bioelectronic applications.
  • Existing methods often lack the spatial resolution and programmability required for complex patterning.

Purpose of the Study:

  • To present a novel method for spatio-temporally controlled electrochemical stimulation of aqueous samples.
  • To demonstrate the capabilities of an integrated CMOS microelectrode array for high-resolution electrochemical patterning.

Main Methods:

  • Utilized a custom-designed CMOS microelectrode array with 131,072 pixels for dense, spatially-addressable electrochemical stimulation.
  • Developed protocols for programmable gold electrodeposition in arbitrary spatial patterns.
  • Demonstrated controllable electrolysis for microscale hydrogen bubble generation.
  • Implemented spatially targeted electrochemical pH modulation.

Main Results:

  • Achieved programmable gold electrodeposition with high spatial accuracy.
  • Successfully generated microscale hydrogen bubbles through controlled electrolysis.
  • Demonstrated precise, localized modulation of pH in aqueous solutions.
  • Validated the potential of the system for complex bioelectronic interfaces.

Conclusions:

  • The integrated CMOS microelectrode array enables unprecedented spatio-temporal control over electrochemical reactions.
  • This technology opens new avenues for high-resolution patterning and manipulation in bioelectronics.
  • The demonstrated capabilities are vital for developing next-generation bioelectronic devices and systems.