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Optogenetic Stimulation of the Auditory Nerve
Published on: October 8, 2014
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Rapid Input-Output Transformation between Local Field Potential and Spiking Activity during Sensation but not Action
Clara Bourrelly1,2, Corentin Massot3,4,2, Neeraj J Gandhi1,5,2
1Departments of Bioengineering neg8@pitt.edu clb240@pitt.edu.
Summary
Local field potential (LFP) activity leads spike bursts in the superior colliculus during visual processing, but spike bursts lead LFP during movement generation. This reveals distinct sensorimotor transformation dynamics.
Area of Science:
- Neuroscience
- Systems Neuroscience
Background:
- Sensorimotor transformation integrates sensory input with motor output.
- Neural activity in the superior colliculus (SC) underlies visually guided eye movements.
- Local field potential (LFP) signals, representing neural input, are understudied in the SC.
Purpose of the Study:
- To compare the temporal dynamics of LFP modulations and spike bursts along the SC's dorsoventral axis.
- To investigate the sequence of neural events during sensorimotor transformation for visually guided saccades.
Main Methods:
- Simultaneous recording of LFP and spike bursts using a laminar probe in the SC of monkeys performing a delayed saccade task.
- Analysis of signal onset times and amplitude transitions across SC layers.
- Trial-by-trial and averaged data analysis.
Main Results:
- Both LFP and spike bursts showed a sensory-to-motor transition from superficial to deeper SC layers.
- LFP modulation preceded spike bursts by <5 ms in superficial/intermediate layers during sensory processing (trial-by-trial).
- Spike bursts led LFP modulation by >25 ms in deeper layers during movement generation.
Conclusions:
- The SC exhibits rapid LFP-to-spike transformation during sensory processing.
- Movement generation involves significant intracollicular processing, with spikes preceding LFP.
- Distinct temporal dynamics of LFP and spiking activity reflect different stages of sensorimotor transformation in the SC.
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