Related Experiment Video
Updated: Jul 31, 2025
06:40
Temporal Analysis of the Nuclear-to-cytoplasmic Translocation of a Herpes Simplex Virus 1 Protein by Immunofluorescent Confocal Microscopy
Published on: November 4, 2018
6.3K
The interactions between PML nuclear bodies and small and medium size DNA viruses
Boris Ryabchenko1, Vojtěch Šroller1, Lenka Horníková1
1Department of Genetics and Microbiology, Faculty of Science, BIOCEV, Charles University, Vestec, 25250, Czech Republic.
Virology Journal
|May 1, 2023
Summary
Promyelocytic leukemia nuclear bodies (PML NBs) interact with DNA viruses, influencing viral replication and host responses. Understanding these complex interactions is crucial for deciphering viral pathogenesis and host defense mechanisms.
Area of Science:
- Cellular Biology
- Virology
- Molecular Biology
Background:
- Promyelocytic leukemia nuclear bodies (PML NBs) are dynamic, membraneless organelles essential for various cellular processes.
- PML NBs are macromolecular protein complexes with a PML protein core and other associated proteins.
Purpose of the Study:
- To review the diverse and complex interactions between small and medium-sized DNA viruses and PML NBs.
- To detail the viral and host factors involved in these interactions and their outcomes.
Main Methods:
- Literature review of studies investigating virus-PML NB interactions.
- Analysis of reported interactions involving specific viral families and PML NB components.
Main Results:
- PML NB components like PML, ATRX/Daxx, Sp100, and p53 interact with various DNA viruses.
- Interactions can inhibit viral replication (adenoviruses, HBV) or promote it (papillomaviruses).
- Polyomaviruses and avian anelloviruses show complex or poorly understood interactions with PML NBs.
Conclusions:
- PML NBs play multifaceted roles in viral infections, acting as both barriers and facilitators of viral propagation.
- Significant gaps remain in understanding the precise mechanisms of virus-PML NB interplay.
- Further research is needed to unravel the complexity of these dynamic interactions.
Related Concept Videos
01:26Size and Structure of Viral Genomes
72
Viral genomes exhibit remarkable diversity in size, structure, and composition, influencing their replication strategies and interactions with host cells. These genomes consist of either DNA or RNA and may be linear or circular. Additionally, they can be single-stranded or double-stranded, with each configuration affecting how the virus propagates within a host. RNA viruses, for instance, generally have smaller genomes than DNA viruses, a factor that contributes to their high mutation rates and...
72
01:38Intralumenal Vesicles and Multivesicular Bodies
3.6K
Intraluminal vesicles (ILVs) are small vesicles 50-80 nm in diameter formed during the maturation of early endosomes. A specialized endosome containing numerous ILVs is called a multivesicular body (MVB). ILVs contain internalized molecules such as antigens, nucleic acids, proteins, and metabolites. Some of these molecules are released from the MVBs inside exosomes and are transported to other cells. Other MVBs contain molecules that are retained in the ILVs and are later degraded within the...
3.6K
01:26DNA Bacteriophages
69
Bacteriophages, or phages, are viruses that specifically infect bacteria, utilizing their genetic material to hijack host cellular machinery for replication. DNA bacteriophages employ single-stranded DNA (ssDNA) or double-stranded DNA (dsDNA) genomes. These phages exhibit diverse replication strategies and host interactions, influencing their ecological roles and applications in biotechnology and medicine.ssDNA BacteriophagesssDNA phages, with their small genomes, utilize unique strategies to...
69
01:29Immune Response Against Viral Pathogens
839
The immune system's response to viral infections is a complex and coordinated process involving natural killer (NK) cells, T cell-mediated responses, and antibody-mediated responses.
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
839
01:10Intracellular Movement of Viruses and Bacteria
2.9K
Intracellular bacteria and viruses often comprise a group of highly infectious pathogens that can cause several diseases. Bacterial pathogens include those belonging to the genus Rickettsia responsible for conditions such as rocky mountain spotted fever and the Mediterranean spotted fever; Chlamydia, a genus responsible for a sexually transmitted disease; Coxiella burnetii, an agent responsible for Q fever. Viral pathogens include vaccinia—a poxvirus, and herpes simplex virus—a...
2.9K
00:56Viral Structure
62.8K
Viruses are extraordinarily diverse in shape and size, but they all have several structural features in common. All viruses have a core that contains a DNA- or RNA-based genome. The core is surrounded by a protective coat of proteins called the capsid. The capsid is composed of subunits called capsomeres. The capsid and genome-containing core are together known as the nucleocapsid.
62.8K