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Cell membrane-coated nanomaterials for cancer therapy
Shiying Zeng1, Qinglai Tang1, Minna Xiao1
1Department of Otorhinolaryngology Head and Neck Surgery, The Second Xiangya Hospital, Central South University, Changsha, 410011, China.
Materials Today. Bio
|May 2, 2023
Summary
Cell membrane-coated nanoparticles (CMNPs) offer improved tumor drug delivery by leveraging natural cell membrane properties. This review explores CMNPs
Area of Science:
- Biomedical Engineering
- Nanotechnology
- Oncology
Background:
- Nanoparticles enhance tumor drug delivery but face challenges like immune clearance and poor targeting.
- Cell membranes offer biocompatibility, targeting, immune evasion, and drug-carrying capacity for improved nanomedicine.
Purpose of the Study:
- To review cell membrane-coated nanoparticles (CMNPs) for tumor therapy.
- To discuss CMNP characteristics, applications, advantages, and limitations in cancer treatment.
Main Methods:
- Review of existing literature on CMNPs in tumor therapy.
- Analysis of cell membrane and nanoparticle properties relevant to CMNP development.
- Discussion of CMNP fabrication, current applications, and future research directions.
Main Results:
- CMNPs combine nanoparticle efficacy with cell membrane benefits for enhanced tumor drug delivery.
- Different cell membranes and nanoparticles offer unique advantages for CMNP design.
- Current applications show promise, but challenges in targeting and toxicity remain.
Conclusions:
- CMNPs represent a promising strategy for advanced tumor drug delivery systems.
- Further research is needed to overcome limitations and optimize CMNPs for clinical cancer therapy.
- This review provides insights into recent progress and future directions for CMNP research.
