The covariance environment defines cellular niches for spatial inference

Doron Haviv1,2, Mohamed Gatie3, Anna-Katerina Hadjantonakis3

  • 1Computational and Systems Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

Summary

New computational methods like COVET and ENVI represent cellular niches using gene covariation. ENVI integrates spatial and single-cell RNA-seq data, improving gene expression imputation and spatial context inference.

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