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An Aging-Susceptible Circadian Rhythm Controls Cutaneous Antiviral Immunity

Stephen Kirchner, Vivian Lei, Paul Kim

    Biorxiv : the Preprint Server for Biology
    |May 3, 2023
    PubMed

    Insights

    Aging skin

    Area of Science:

    • Immunology
    • Dermatology
    • Chronobiology

    Background:

    • Aged skin exhibits increased susceptibility to viral infections.
    • The underlying mechanisms of this immunosenescence-related immune risk are not fully understood.

    Conclusions:

    • Aged skin's antiviral immunity is regulated by an evolutionarily conserved, age-sensitive circadian mechanism.
    • Restoring circadian function presents a promising antiviral strategy for combating infections in aging individuals.

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