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Review on kidney diseases: types, treatment and potential of stem cell therapy

Jaspreet Singh1, Sanjeev Singh1

  • 1School of Bioengineering & Biosciences, Lovely Professional University, 15935, Block 56, Room No 202, Phagwara, Punjab 144411 India.

Renal Replacement Therapy
|May 3, 2023
PubMed

Insights

Stem cell therapy offers a promising approach for renal repair in acute and chronic kidney diseases. This review explores stem cell mechanisms, outcomes, limitations, and advancements in regenerative medicine for kidney disorders.

Area of Science:

  • Nephrology
  • Regenerative Medicine
  • Stem Cell Biology

Background:

  • Renal disorders represent a growing global health concern.
  • Current supportive therapies have limitations in promoting renal repair.
  • Stem cell technology presents a novel therapeutic avenue for kidney diseases.

Purpose of the Study:

  • To review the landscape of renal diseases, including acute and chronic kidney disease.
  • To explore the potential of stem cell therapy in treating and repairing damaged renal cells.
  • To discuss the mechanisms, outcomes, limitations, and advancements in stem cell therapy for renal repair.

Main Methods:

  • Literature review of renal disorders and current treatments.
  • Analysis of stem cell therapy mechanisms and reported outcomes.
  • Examination of advanced stem cell approaches such as PiggyBac, Sleeping Beauty, and Sendai virus.
  • Focus on paracrine activities of various stem cell types including amniotic fluid stem cells, renal stem cells, embryonic stem cells, mesenchymal stem cells, and induced pluripotent stem cells.

Main Results:

  • Stem cells possess self-renewal and proliferative properties beneficial for disease treatment.
  • Various stem cell types (AFSCs, RSCs, ESCs, MSCs, iPSCs) show potential for renal repair.
  • Advanced techniques are improving the efficacy and application of stem cell therapy.
  • Paracrine mechanisms are crucial in the regenerative potential of stem cells for kidney disorders.

Conclusions:

  • Stem cell therapy is a promising strategy for managing renal disorders.
  • Understanding stem cell mechanisms and optimizing delivery methods are key to successful renal repair.
  • Continued research into regenerative medicine is essential for overcoming limitations and advancing kidney disease treatment.
Keywords:
Acute kidney injuryChronic kidney diseasesMedicine for kidney diseasesStem cells

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