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Essential Trace Elements in Patients with Dyslipidemia: A Meta-analysis
Cui-Ping Li1, Yu-Xin Song1, Zi-Jun Lin1
1School of Medicine, Taizhou University, Jiaojiang, Zhejiang, 318000, China.
Current Medicinal Chemistry
|May 3, 2023
Summary
Serum trace elements like iron, selenium, copper, chromium, and manganese are linked to hyperlipidemia. Zinc showed no significant association with dyslipidemia, but copper and calcium may influence lipid metabolism.
Area of Science:
- Biochemistry
- Human Physiology
- Nutritional Science
Background:
- Lipid metabolism encompasses crucial processes like uptake, transport, synthesis, and degradation.
- Trace elements play a vital role in maintaining normal human lipid metabolism.
- This study investigates the intricate relationship between serum trace elements and lipid metabolism.
Purpose of the Study:
- To systematically review and meta-analyze the association between serum trace elements and lipid metabolism.
- To explore the impact of specific trace elements (zinc, iron, calcium, copper, chromium, manganese, selenium) on lipid profiles.
- To identify conclusive and inconclusive findings regarding trace element levels and lipid metabolism disorders.
Main Methods:
- Systematic review and meta-analysis of published articles.
- Literature search conducted across PubMed, Web of Science, CNKI, and Wanfang databases.
- Data analysis performed using Review Manager 5.3, covering publications from January 1, 1900, to July 12, 2022.
Main Results:
- Serum zinc levels did not show a significant association with dyslipidemia.
- Serum iron, selenium, copper, chromium, and manganese were found to be associated with hyperlipidemia.
- The study identified specific trace elements linked to altered lipid profiles.
Conclusions:
- Serum zinc, copper, and calcium content may be related to lipid metabolism.
- Findings on the relationship between lipid metabolism and iron, manganese remain inconclusive.
- Further research is warranted to elucidate the role of selenium in lipid metabolism disorders and explore trace element-based therapeutic strategies.
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