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Updated: Jul 31, 2025
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Live Imaging and Quantification of Viral Infection in K18 hACE2 Transgenic Mice Using Reporter-Expressing Recombinant SARS-CoV-2
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OPTN/SRTR 2021 Annual Data Report: COVID-19
Jonathan M Miller1, Yoon Son Ahn2, Allyson Hart1
1Scientific Registry of Transplant Recipients, Hennepin Healthcare Research Institute, Minneapolis, MN; Department of Medicine, Hennepin Healthcare, University of Minnesota, Minneapolis, MN.
Summary
Organ transplantation rates have recovered post-pandemic, but COVID-19 continues to impact patient survival and graft success, particularly for kidney transplant candidates. Continued focus is needed to reduce mortality and graft failure.
Area of Science:
- Medicine
- Immunology
- Public Health
Background:
- The COVID-19 pandemic initially disrupted organ transplantation systems globally.
- Understanding the pandemic's ongoing impact on transplantation outcomes is crucial.
Purpose of the Study:
- To provide an updated analysis of organ transplantation trends through February 12, 2022.
- To examine COVID-19-specific mortality on waiting lists and post-transplant.
- To assess graft failure rates in the context of the pandemic.
Main Methods:
- Analysis of organ transplantation data, including waiting list and post-transplant outcomes.
- Tracking trends through February 2022, updating previous reports.
- Focusing on COVID-19 as a cause of death and its correlation with pandemic waves.
Main Results:
- Transplant rates have recovered to or surpassed pre-pandemic levels for all organs.
- Post-transplant mortality and graft failure rates increased, correlating with pandemic waves.
- COVID-19-related waitlist mortality is a significant concern, especially for kidney recipients.
Conclusions:
- The organ transplantation system demonstrates sustained recovery one year into the pandemic.
- Reducing COVID-19-related mortality and graft failure remains a critical challenge.
- Targeted interventions are necessary to mitigate the pandemic's impact on transplant recipients.
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